IMR Press / FBL / Volume 13 / Issue 15 / DOI: 10.2741/3128

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Liver receptor homolog-1, an emerging metabolic modulator
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1 Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030

*Author to whom correspondence should be addressed.

Front. Biosci. (Landmark Ed) 2008, 13(15), 5950–5958;
Published: 1 May 2008

The liver receptor homolog-1 (LRH-1; NR5A2) belongs to nuclear hormone receptor superfamily, and is expressed mainly in the liver, intestine, exocrine pancreas, and ovary. It binds DNA as a monomer, and is best known as a regulator of hepatic expression of the key bile acid biosynthetic enzyme cholesterol 7alpha hydroxylase (Cyp7A1). It is also expressed in embryonic stem cells and the initial stages of embryonic development, and the very early lethality of LRH-1 knockout mice highlights its essential developmental role. Recent crystal structures of LRH-1 and its closest relative steroidogenic factor-1 (SF-1; NR5A1) identified phospholipids as potential ligands. This intriguing discovery raises the possibility of an unexpected new class of nuclear receptor signaling molecules, but the broader functional roles of LRH-1 and these new ligands remain to be established.

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