IMR Press / FBL / Volume 13 / Issue 14 / 10.2741/3083

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Does deep brain stimulation induce apathy in parkinson's disease?

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1 University of Florida Department of Clinical and Health Psychology, P.O. Box 100165, Gainesville, FL 32610
Academic Editor:Michael Okun
Front. Biosci. (Landmark Ed) 2008, 13(14), 5316–5322;
Published: 1 May 2008

Chronic deep brain stimulation (DBS) is an important therapeutic advancement for the treatment of motor symptoms in Parkinson's disease (PD). However, its effects on non-motor symptoms are not well understood. Several studies have reported motivational disturbances and apathy after DBS surgery. Recent studies are beginning to more carefully examine the relationship between DBS and apathy. This review summarizes and evaluates the current state of the literature on apathy after DBS surgery, discusses methodological limitations in the literature, and makes suggestions for future research.

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