IMR Press / FBL / Volume 12 / Issue 13 / DOI: 10.2741/2551

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Mechanobiology of mesenchymal stem cells and their use in cardiovascular repair
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1 Department of Bioengineering and The Center for Tissue Bioengineering, University of California-Berkeley, Berkeley, CA, Joint Graduate Group, University of California, San Francisco and Berkeley, , Berkeley, CA, USA
Academic Editor:Song Li
Front. Biosci. (Landmark Ed) 2007, 12(13), 5098–5116;
Published: 1 September 2007
(This article belongs to the Special Issue Stem cell engineering)

Mesenchymal stem cells (MSCs) derived from bone marrow have shown great promise in tissue repair. While these cells induce little immune response, they show marked self-renewal properties and can differentiate into many cell types. Recent evidence shows that mechanical factors such as fluid shear stress, mechanical strain and the rigidity of extracellular matrix can regulate the proliferation and differentiation of MSCs through various signaling pathways. Transplanted MSCs enhance angiogenesis and contribute to remodeling of the vasculature. In this review, we will focus on the responses of vascular cells and MSCs to shear stress, strain and matrix rigidity and will discuss the use of MSCs in myocardial repair and vascular tissue engineering.

mesenchymal stem cell
smooth muscle cell
endothelial cell
mechanical strain
shear stress
tissue engineered vascular graft
cardiac repair
cardiovascular therapy
myocardial infarction
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