IMR Press / FBL / Volume 12 / Issue 11 / DOI: 10.2741/2393

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Induction of autoimmunity after allotransplantation
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1 Department of Surgery, Transplantation Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
2 Departmens of Medicine, Microbiology and Immunology, and Center for Immunobiology, Indiana University School of Medicine, Indianapolis, Indiana
Academic Editor:Gilles Benichou
Front. Biosci. (Landmark Ed) 2007, 12(11), 4362–4369; https://doi.org/10.2741/2393
Published: 1 May 2007
(This article belongs to the Special Issue New insights in transplantation tolerance)
Abstract

Our studies show that activated autoreactive inflammatory T cells specific and autoantibodies to collagen (V) and cardiac myosin are consistently detected after lung and heart transplantation, respectively. Clonal expansion of these T cells occurs only after an alloresponse, but once activated they can induce on their own rejection of allogeneic and even syngeneic transplants. Indirect rather than indirect alloresponse triggers autoimmunity after transplantation presumably via antigen mimicry between autoantigen peptides and donor MHC peptides. Also, it is plausible that inflammation and tissue damage associated with initial alloresponse to donor MHC antigens causes the release of formerly sequestered autoantigens. This may result in the presentation of some cryptic self-determinants thereby triggering an autoimmune process at the site of the graft. Finally, tolerance induction to cardiac myosin and collagen (V) results in long-term survival and reduced pathogenesis of heart and lung allografts, respectively. This suggests that, after transplantation, the inflammatory alloresponse to donor MHC triggers a cascade of events including autoimmunity to tissue antigens, a phenomenon that is essential to the actual rejection.

Keywords
Autoimmune Disease
Transplantation
T Cells
Allorecognition
Lung
Heart
Review
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