IMR Press / FBL / Volume 12 / Issue 11 / DOI: 10.2741/2394

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Notch signaling and its role in breast cancer
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1 Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
Academic Editor:Kounosuke Watabe
Front. Biosci. (Landmark Ed) 2007, 12(11), 4370–4383; https://doi.org/10.2741/2394
Published: 1 May 2007
(This article belongs to the Special Issue Pathogenesis of tumor progression in breast and prostate cancer)
Abstract

The Notch signaling plays a key role in cell differentiation, survival, and proliferation through diverse mechanisms. Thus, alterations of the Notch signaling can lead to a variety of disorders including human malignancies. In this review, we will focus on recent advancements in identification of aberrant Notch signaling in cancer, and the possible underlying mechanisms in breast cancer. We will also highlight the therapeutic potential of targeting Notch for cancer treatment.

Keywords
Notch Signaling
Tumorigenesis
Breast Cancer
Review
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