IMR Press / FBL / Volume 12 / Issue 11 / DOI: 10.2741/2391

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Tetraplex DNA and its interacting proteins
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1 Department of Biochemistry, Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 31096, Israel
Academic Editor:Sergei Mirkin
Front. Biosci. (Landmark Ed) 2007, 12(11), 4336–4351;
Published: 1 May 2007
(This article belongs to the Special Issue DNA structures, genome instability and human disease)

Mounting evidence indicates that certain nucleotide sequences impose non-canonical secondary structures on DNA. The resulting variable conformations are thought to bestow on the DNA informational content additional to that encoded by its linear arrangement of bases. DNA sequences that include clusters of contiguous guanine residues readily form in vitro diverse types of four-stranded structures collectively named tetraplex or quadruplex DNA. Data suggest that tetraplex DNA structures are likely to be formed in vivo and to have roles in key biological processes such as regulation of gene transcription, maintenance of telomeres, DNA recombination and the packaging of retroviral genome. A credible argument for the existence of quadruplex DNA in vivo is the prevalence of numerous viral and cellular proteins that interact physically and functionally with tetrahelical DNA. Some such proteins bind selectively and tightly to tetraplex DNA, others promote the formation of DNA tetrahelices or act to unwind them, and several nucleases cleave tetraplex DNA preferentially. The protein-mediated structural transformations of quadruplex DNA and its selective nucleolytic cleavage argue strongly for transient formation of tetrahelical DNA in the cell. This review surveys tetraplex structures of DNA and their interacting proteins and appraises the evidence for their biological roles.

Tetraplex DNA
Quadruplex DNA
Tetrahelical DNA
Guanine quartets
Telomere DNA
DNA Recombination
Transcriptional regulation
Nucleotide expansion disorders
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