IMR Press / FBL / Volume 11 / Issue 1 / DOI: 10.2741/1860

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Chemokines in Tumor Immunotherapy

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1 Department of Pathology, Columbia University, New York, NY 10032, USA
2 Department of Surgery, Columbia University, New York, NY 10032, USA
Front. Biosci. (Landmark Ed) 2006, 11(1), 1024–1030;
Published: 1 January 2006

The chemokines are a family of small molecules that mediate cell migration, activation, differentiation, angiogenesis, and perhaps other functions. The chemokines have been classified by their amino acid composition, functional activity, and receptor binding properties. The chemokines receptors are 7 transmembrane G proteins and there is considerable redundancy in ligand specificity. The role of chemokines in cancer is not well understood, but there is accumulating evidence that they play a major role in both tumorigenesis and the host immune response to tumors. Thus, chemokines and their receptors represent potential therapeutic targets for drug development. This article will briefly review the current understanding of chemokines biology of defined chemokines that are thought to be involved in tumor growth, metastasis, and the host immune response against cancer.

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