IMR Press / FBE / Volume 8 / Issue 2 / DOI: 10.2741/E764

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Biology and treatment of metastasis of sarcoma to the brain

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1 Department of Pathology, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC, 27157
2 Department of Radiation Oncology, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC, 27157
3 Departments of Hematology and Oncology, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC, 27157
4 Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC, 27157

*Author to whom correspondence should be addressed.

Academic Editor: Kounosuke Watabe

Front. Biosci. (Elite Ed) 2016, 8(2), 233–244; https://doi.org/10.2741/E764
Published: 1 January 2016
(This article belongs to the Special Issue Pathogenesis of tumor progression in breast and prostate cancer)
Abstract

Sarcomas are rare tumors with devastating clinical consequences, often affecting children as well as adults. Brain metastasis in sarcoma is frequently preceded by lung metastasis. Common offenders include Ewing sarcoma, osteosarcoma and leiomyosarcoma. Although our understanding of sarcoma metastasis remains limited, several cellular factors and signaling pathways appear to play regulatory roles and/or exhibit prognostic values in sarcoma metastasis. In addition, MicroRNAs have been shown to have either positive or negative impact on sarcoma biology and metastasis. Sarcoma is considered one of the classic radio- and chemo-resistant brain metastasis, hence the use of multiple modalities in order to improve the therapeutic ratio and overcome the inherent resistance. Treatment modalities include surgical resection, chemotherapy, gamma knife radiosurgery and/or fractionated whole-brain radiotherapy. The efficacy of chemotherapy is limited by the ability of the drug(s) to cross the blood-brain barrier (BBB), and the chemosensitivity of the tumor to the chemotherapeutic agent. In this review, we discuss the pathology, biology and therapy for sarcoma brain metastasis.

Keywords
Sarcoma
Brain Metastasis
Biology
Oncoprotein
Therapy
Review
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