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[1]F.O. Netto, I.M. Diniz, S.M. Grossmann, M.H. de Abreu, M.A. do Carmo, M.C. Aguiar: Risk factors in burning mouth syndrome: a case-control study based on patient records. Clin Oral Investig 15, 571–575 (2011)
[2]P.J. Lamey, A.B. Lamb: Prospective study of aetiological factors in burning mouth syndrome. Br Med J (Clin Res Ed) 296, 1243-1246 (1988)
[3]J.H. Meurman, L. Tarkkila, A. Tiitinen: The menopause and oral health. Maturitas 63, 56-62 (2009)
[4]JE. Fantasia: Diagnosis and treatment of common oral lesions found in the elderly. Dent Clin North Am 41, 877-890 (1997)
[5]Z. Yilmaz, T. Renton, Y. Yiangou, J. Zakrzewska, I.P. Chessell, C. Bountra, P. Anand: Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score. J Clin Neurosci 14, 864-871 (2007)
[6]M. Grushka, J.B. Epstein, M. Gorsky: Burning mouth syndrome and other oral sensorydisorders: a unifying hypothesis. Pain Res Manag 8, 133-135 (2003)
[7]G.E. Gurvits, A. Tan: Burning mouth syndrome. World J Gastroenterol 19, 665-672 (2013)
[8]J.A. Lipton, J.A. Ship, D. Larach-Robinson: Estimated prevalence and distribution of reported orofacial pain in the United States. J Am Dent Assoc 124, 115-121 (1993)
[9]T. Tammiala-Salonen, T. Hiidenkari, T. Parvinen: Burning mouth in a Finnish adult population. Community Dent Oral Epidemiol 21, 67-71 (1993)
[10]M. Srinivasan, K.N. Kodumudi, S.L. Zunt: Soluble CD14 and toll-like receptor-2 are potential salivary biomarkers for oral lichen planus and burning mouth syndrome. Clin Immunol 126, 31-37 (2008)
[11]H. Terai, M. Shimahara: Glossodynia from Candida-associated lesions, burning mouth syndrome, or mixed causes. Pain Med 11, 856-860 (2010)
[12]A. Lucchese, A. Guida, R. Serpico: Glossodynia and coeliac disease. Immuno pharmacol Immunotoxicol 34, 247-249 (2012)
[13]M. Uten-Shorrer, J.M. Kelley, S.T. Sonis, N,S. Treister: Placebo effect in burning mouth syndrome: a systematic review. Oral Dis 20, 1-6 (2014)
[14]G. Lauria, A. Majorana, M. Borgna, R. Lombardi, P. Penza, A. Padovani, P. Sapelli: Trigeminal small fiber sensory neuropathy causes burning mouth syndrome. Pain 115, 332-337 (2005)
[15]H. Forssell, S. Jääskeläinen, O. Tenovuo, S. Hinkka: Sensory dysfunction in burning mouth syndrome. Pain 99, 41-47 (2002)
[16]H.P. Lin, Y.P. Wang, H.M. Chen, Y.S. Kuo, M.J. Lang, A. Sun: Significant association ofhematinic deficiencies and high blood homocysteine levels with burning mouth syndrome. J Formos Med Assoc 112, 319-325 (2013)
[17]M. Corsalini, D. Di Venere, F. Pettini, D. Lauritano, M. Petruzzi: Temporomandibular disorders in burning mouth syndrome patients: an observational study. Int J Med Sci 10, 1784-1789 (2013)
[18]D.I. Friedman: Topirimate-induced burning mouth syndrome. Headache 50, 1383-1385 (2010)
[19]E.A. Coon, R.S. Laughlin: Burning mouth syndrome in Parkinson’s disease: dopamine ascure or cause? J Headache Pain 13, 255-257 (2012)
[20]L. 4th. Charleston: Burning mouth syndrome: a review of recent literature. Curr Pain Headache Rep 17, 336 (2013)
[21]N. Chainani-Wu, E. Madden, S. Jr. Silverman: A case-control study of burning mouthsyndrome and sleep dysfunction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112, 203-208 (2011)
[22]O. Komiyama, H. Nishimura, Y. Makiyama, T. Iida, R. Obara, M. Shinoda, M. Kobayashi, N. Noma, O. Abe, A. De Laat, M. Kawara: Group cognitive behavioral intervention for patients with burning mouth syndrome. J Oral Sci 55, 17-22 (2013)
[23]F.T. De Souza, A.L. Teixeira, T.M. Amaral, T.P. dos Santos, M.H. Abreu, T.A. Silva, A. Kummer: Psychiatric disorders in burning mouth syndrome. J Psychosom Res 72, 142- 146 (2012)
[24]G.D. Klasser, J.B. Epstein, D. Villines: Diagnostic dilemma: the enigma of an oral burning sensation. J Can Dent Assoc 77, 146 (2011)
[25]E. Liav, B. Kamran, R. Schaham, R. Czerninski, R.H. Gracely, R. Benoliel: Evidenceof chorda tympani dysfunction in patients with burning mouth syndrome. J Am Dent Assoc 138, 628-633 (2007)
[26]L.L. Patton, M.A. Siegel, R. Benoliel, A. De Laat: Management of burning mouth syndrome: systematic review and management recommendations. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103, 1-13 (2007)
[27]A. Scala, L. Checchi, M. Montevecchi, I. Marini, M.A. Giamberardino: Update on burning mouth syndrome: overview and patient management. Crit Rev Oral Biol Med 14, 275-291 (2003)
[28]M. Grushka, J.B. Epstein, M. Gorsky: Burning mouth syndrome and other oral sensory disorders: a unifying hypothesis. Pain Res Manag 8, 133-135 (2003)
[29]N. Hagelberg, H. Forssell, J.O. Rinne, H. Scheinin, T. Taiminen, S. Aalto, S. Luutonen, K. Någren, S. Jääskeläinen: Striatal dopamine D1 and D2 receptors in burning mouth syndrome. Pain 101, 149-154 (2003)
[30]R.J. Albuquerque, R. de Leeuw, C.R. Carlson, J.P. Okeson, C.S. Miller, A.H. Andersen: Cerebral activation during thermal stimulation of patients who have burning mouth disorder: an fMRI study. Pain 122, 223-234 (2006)
[31]T.M. Gajjar, L.I. Anderson, D.E. Dluzen: Acute effects of estrogen uponmethamphetamine induced neurotoxicity of the nigrostriatal dopaminergic system. J Neural Transm 110, 1215-1224 (2003)
[32]D.B. Miller, S.F. Ali, J.P. O’Callaghan, S.C. Laws: The impact of gender and estrogen on striatal dopaminergic neurotoxicity. Ann N Y Acad Sci 844, 153-165 (1998)
[33]H.S. Kho, J.Y. Chang, Y.Y. Kim, Y. Kim: MUC1 and Toll-like receptor-2 expression in burning mouth syndrome and oral lichen planus. Arch Oral Biol 58, 837-842 (2013)
[34]A. Sun, K.M. Wu, Y.P. Wang, H.P. Lin, H.M. Chen, C.P. Chiang: Burning mouth syndrome: a review and update. J Oral Pathol Med 42, 649-655 (2013)
[35]P. López-Jornet, F. Camacho-Alonso, P. Andujar-Mateos, M. Sánchez-Siles, F. Gómez-Garcia: Burning mouth syndrome: an update. Med Oral Patol Oral Cir Bucal 15, 562-568 (2010)
[36]J.B. Epstein, J.H. Marcoe: Topical application of capsaicin for treatment of oral neuropathic pain and trigeminal neuralgia. Oral Surg Oral Med Oral Pathol 77, 135-140 (1994)
[37]F.J. Silvestre, J. Silvestre-Rangil, C. Tamarit-Santafé, D. Bautista: Application of a capsaicin rinse in the treatment of burning mouth syndrome. Med Oral Patol Oral Cir Bucal 17, 1-4 (2012)
[38]C. Grémeau-Richard, C. Dubray, B. Aublet-Cuvelier, S. Ughetto, A. Woda: Effect of lingual nerve block on burning mouth syndrome (stomatodynia): a randomized crossover trial. Pain 149, 27–32 (2010)
[39]K.E. Barker, M.D. Batstone, N.W. Savage: Comparison of treatment modalities in burning mouth syndrome. Aust Dent J 54, 300-305 (2009)
[40]A. Sardella, D. Uglietti, F. Demarosi, G. Lodi, C. Bez, A. Carrassi: Benzydamine hydrochloride oral rinses in management of burning mouth syndrome. A clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 88, 683-686 (1999)
[41]P. López-Jornet, F. Camacho-Alonso, D. Molino-Pagan: Prospective, randomized, double-blind, clinical evaluation of Aloe vera Barbadensis, applied incombination with a tongue protector to treat burning mouth syndrome. J Oral Pathol Med 42, 295-301 (2013)
[42]M. Petruzzi, D. Lauritano, M. De Benedittis, M. Baldoni, R. Serpico: Systemic capsaicin for burning mouth syndrome: short-term results of a pilot study. J Oral Pathol Med 33, 111-114 (2004)
[43]K. Amos, S.C. Yeoh, C.S. Farah: Combined topical and systemic clonazepam therapyf or the management of burning mouth syndrome: a retrospective pilot study. J Orofac Pain 25, 125-130 (2011)
[44]A. Sardella, G. Lodi, F. Demarosi, C. Bez, S. Cassano, A. Carrassi: Burning mouth syndrome: a retrospective study investigating spontaneous remission and response to treatments. Oral Dis 12, 152-155 (2006)
[45]D.R. Cavalcanti, F.R. da Silveira: Alpha lipoic acid in burning mouth syndrome: a randomized double-blind placebo-controlled trial. J Oral Pathol Med 38, 254-261 (2009)
[46]J. Bergdahl, G. Anneroth, H. Perris: Cognitive therapy in the treatment of patients with resistant burning mouth syndrome: a controlled study. J Oral Pathol Med 24, 213-215 (1995)
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Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
An overview of burning mouth syndrome
1 Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, Second University of Naples, Via Luigi de Crecchio, 6, 80138 Naples, Italy
2 Section of Odontostomatology, University of Bari “Aldo Moro”, Bari, Italy
3 Department of Neuroscience and Biomedical Tecnologies. University of Milan- Bicocca Monza, Italy
*Author to whom correspondence should be addressed.
Abstract
Burning mouth syndrome (BMS) is characterised by the presence of a burning sensation in the oral mucosa in the absence of any clinically apparent mucosal sign. It occurs more commonly in older women and often affects the tongue tip and lateral borders, lips, and hard and soft palates. Besides the burning sensation, patients with BMS may complain of unremitting oral mucosal pain, dysgeusia, and xerostomia. The exact pathophysiology of primary BMS remains unknown. A major challenge for the clinician is the treatment of BMS: identifying possible causative factors is the first step, but BMS is often idiopathic. Drug therapy, in addition to behavioural therapy and psychotherapy, may help to eliminate the symptoms. Considering the growing incidence of BMS in older people, further research is required to determine the true efficacy of current management strategies for patients with this disorder.
Keywords
- Burning Mouth Syndrome
- Chronic Pain
- Oral Pain
- Oral Health
- Review
References
- [1] F.O. Netto, I.M. Diniz, S.M. Grossmann, M.H. de Abreu, M.A. do Carmo, M.C. Aguiar: Risk factors in burning mouth syndrome: a case-control study based on patient records. Clin Oral Investig 15, 571–575 (2011)
- [2] P.J. Lamey, A.B. Lamb: Prospective study of aetiological factors in burning mouth syndrome. Br Med J (Clin Res Ed) 296, 1243-1246 (1988)
- [3] J.H. Meurman, L. Tarkkila, A. Tiitinen: The menopause and oral health. Maturitas 63, 56-62 (2009)
- [4] JE. Fantasia: Diagnosis and treatment of common oral lesions found in the elderly. Dent Clin North Am 41, 877-890 (1997)
- [5] Z. Yilmaz, T. Renton, Y. Yiangou, J. Zakrzewska, I.P. Chessell, C. Bountra, P. Anand: Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score. J Clin Neurosci 14, 864-871 (2007)
- [6] M. Grushka, J.B. Epstein, M. Gorsky: Burning mouth syndrome and other oral sensorydisorders: a unifying hypothesis. Pain Res Manag 8, 133-135 (2003)
- [7] G.E. Gurvits, A. Tan: Burning mouth syndrome. World J Gastroenterol 19, 665-672 (2013)
- [8] J.A. Lipton, J.A. Ship, D. Larach-Robinson: Estimated prevalence and distribution of reported orofacial pain in the United States. J Am Dent Assoc 124, 115-121 (1993)
- [9] T. Tammiala-Salonen, T. Hiidenkari, T. Parvinen: Burning mouth in a Finnish adult population. Community Dent Oral Epidemiol 21, 67-71 (1993)
- [10] M. Srinivasan, K.N. Kodumudi, S.L. Zunt: Soluble CD14 and toll-like receptor-2 are potential salivary biomarkers for oral lichen planus and burning mouth syndrome. Clin Immunol 126, 31-37 (2008)
- [11] H. Terai, M. Shimahara: Glossodynia from Candida-associated lesions, burning mouth syndrome, or mixed causes. Pain Med 11, 856-860 (2010)
- [12] A. Lucchese, A. Guida, R. Serpico: Glossodynia and coeliac disease. Immuno pharmacol Immunotoxicol 34, 247-249 (2012)
- [13] M. Uten-Shorrer, J.M. Kelley, S.T. Sonis, N,S. Treister: Placebo effect in burning mouth syndrome: a systematic review. Oral Dis 20, 1-6 (2014)
- [14] G. Lauria, A. Majorana, M. Borgna, R. Lombardi, P. Penza, A. Padovani, P. Sapelli: Trigeminal small fiber sensory neuropathy causes burning mouth syndrome. Pain 115, 332-337 (2005)
- [15] H. Forssell, S. Jääskeläinen, O. Tenovuo, S. Hinkka: Sensory dysfunction in burning mouth syndrome. Pain 99, 41-47 (2002)
- [16] H.P. Lin, Y.P. Wang, H.M. Chen, Y.S. Kuo, M.J. Lang, A. Sun: Significant association ofhematinic deficiencies and high blood homocysteine levels with burning mouth syndrome. J Formos Med Assoc 112, 319-325 (2013)
- [17] M. Corsalini, D. Di Venere, F. Pettini, D. Lauritano, M. Petruzzi: Temporomandibular disorders in burning mouth syndrome patients: an observational study. Int J Med Sci 10, 1784-1789 (2013)
- [18] D.I. Friedman: Topirimate-induced burning mouth syndrome. Headache 50, 1383-1385 (2010)
- [19] E.A. Coon, R.S. Laughlin: Burning mouth syndrome in Parkinson’s disease: dopamine ascure or cause? J Headache Pain 13, 255-257 (2012)
- [20] L. 4th. Charleston: Burning mouth syndrome: a review of recent literature. Curr Pain Headache Rep 17, 336 (2013)
- [21] N. Chainani-Wu, E. Madden, S. Jr. Silverman: A case-control study of burning mouthsyndrome and sleep dysfunction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112, 203-208 (2011)
- [22] O. Komiyama, H. Nishimura, Y. Makiyama, T. Iida, R. Obara, M. Shinoda, M. Kobayashi, N. Noma, O. Abe, A. De Laat, M. Kawara: Group cognitive behavioral intervention for patients with burning mouth syndrome. J Oral Sci 55, 17-22 (2013)
- [23] F.T. De Souza, A.L. Teixeira, T.M. Amaral, T.P. dos Santos, M.H. Abreu, T.A. Silva, A. Kummer: Psychiatric disorders in burning mouth syndrome. J Psychosom Res 72, 142- 146 (2012)
- [24] G.D. Klasser, J.B. Epstein, D. Villines: Diagnostic dilemma: the enigma of an oral burning sensation. J Can Dent Assoc 77, 146 (2011)
- [25] E. Liav, B. Kamran, R. Schaham, R. Czerninski, R.H. Gracely, R. Benoliel: Evidenceof chorda tympani dysfunction in patients with burning mouth syndrome. J Am Dent Assoc 138, 628-633 (2007)
- [26] L.L. Patton, M.A. Siegel, R. Benoliel, A. De Laat: Management of burning mouth syndrome: systematic review and management recommendations. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103, 1-13 (2007)
- [27] A. Scala, L. Checchi, M. Montevecchi, I. Marini, M.A. Giamberardino: Update on burning mouth syndrome: overview and patient management. Crit Rev Oral Biol Med 14, 275-291 (2003)
- [28] M. Grushka, J.B. Epstein, M. Gorsky: Burning mouth syndrome and other oral sensory disorders: a unifying hypothesis. Pain Res Manag 8, 133-135 (2003)
- [29] N. Hagelberg, H. Forssell, J.O. Rinne, H. Scheinin, T. Taiminen, S. Aalto, S. Luutonen, K. Någren, S. Jääskeläinen: Striatal dopamine D1 and D2 receptors in burning mouth syndrome. Pain 101, 149-154 (2003)
- [30] R.J. Albuquerque, R. de Leeuw, C.R. Carlson, J.P. Okeson, C.S. Miller, A.H. Andersen: Cerebral activation during thermal stimulation of patients who have burning mouth disorder: an fMRI study. Pain 122, 223-234 (2006)
- [31] T.M. Gajjar, L.I. Anderson, D.E. Dluzen: Acute effects of estrogen uponmethamphetamine induced neurotoxicity of the nigrostriatal dopaminergic system. J Neural Transm 110, 1215-1224 (2003)
- [32] D.B. Miller, S.F. Ali, J.P. O’Callaghan, S.C. Laws: The impact of gender and estrogen on striatal dopaminergic neurotoxicity. Ann N Y Acad Sci 844, 153-165 (1998)
- [33] H.S. Kho, J.Y. Chang, Y.Y. Kim, Y. Kim: MUC1 and Toll-like receptor-2 expression in burning mouth syndrome and oral lichen planus. Arch Oral Biol 58, 837-842 (2013)
- [34] A. Sun, K.M. Wu, Y.P. Wang, H.P. Lin, H.M. Chen, C.P. Chiang: Burning mouth syndrome: a review and update. J Oral Pathol Med 42, 649-655 (2013)
- [35] P. López-Jornet, F. Camacho-Alonso, P. Andujar-Mateos, M. Sánchez-Siles, F. Gómez-Garcia: Burning mouth syndrome: an update. Med Oral Patol Oral Cir Bucal 15, 562-568 (2010)
- [36] J.B. Epstein, J.H. Marcoe: Topical application of capsaicin for treatment of oral neuropathic pain and trigeminal neuralgia. Oral Surg Oral Med Oral Pathol 77, 135-140 (1994)
- [37] F.J. Silvestre, J. Silvestre-Rangil, C. Tamarit-Santafé, D. Bautista: Application of a capsaicin rinse in the treatment of burning mouth syndrome. Med Oral Patol Oral Cir Bucal 17, 1-4 (2012)
- [38] C. Grémeau-Richard, C. Dubray, B. Aublet-Cuvelier, S. Ughetto, A. Woda: Effect of lingual nerve block on burning mouth syndrome (stomatodynia): a randomized crossover trial. Pain 149, 27–32 (2010)
- [39] K.E. Barker, M.D. Batstone, N.W. Savage: Comparison of treatment modalities in burning mouth syndrome. Aust Dent J 54, 300-305 (2009)
- [40] A. Sardella, D. Uglietti, F. Demarosi, G. Lodi, C. Bez, A. Carrassi: Benzydamine hydrochloride oral rinses in management of burning mouth syndrome. A clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 88, 683-686 (1999)
- [41] P. López-Jornet, F. Camacho-Alonso, D. Molino-Pagan: Prospective, randomized, double-blind, clinical evaluation of Aloe vera Barbadensis, applied incombination with a tongue protector to treat burning mouth syndrome. J Oral Pathol Med 42, 295-301 (2013)
- [42] M. Petruzzi, D. Lauritano, M. De Benedittis, M. Baldoni, R. Serpico: Systemic capsaicin for burning mouth syndrome: short-term results of a pilot study. J Oral Pathol Med 33, 111-114 (2004)
- [43] K. Amos, S.C. Yeoh, C.S. Farah: Combined topical and systemic clonazepam therapyf or the management of burning mouth syndrome: a retrospective pilot study. J Orofac Pain 25, 125-130 (2011)
- [44] A. Sardella, G. Lodi, F. Demarosi, C. Bez, S. Cassano, A. Carrassi: Burning mouth syndrome: a retrospective study investigating spontaneous remission and response to treatments. Oral Dis 12, 152-155 (2006)
- [45] D.R. Cavalcanti, F.R. da Silveira: Alpha lipoic acid in burning mouth syndrome: a randomized double-blind placebo-controlled trial. J Oral Pathol Med 38, 254-261 (2009)
- [46] J. Bergdahl, G. Anneroth, H. Perris: Cognitive therapy in the treatment of patients with resistant burning mouth syndrome: a controlled study. J Oral Pathol Med 24, 213-215 (1995)
