IMR Press / FBE / Volume 5 / Issue 1 / DOI: 10.2741/E614

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Experimental models of lung transplantation

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1 Department of Surgery Washington University in St. Louis 660 South Euclid Avenue, St. Louis, MO 63110-1013, USA
2 Department of Pathology and Immunology, Washington University in St. Louis 660 South Euclid Avenue, St. Louis, MO 63110-1013, USA

*Author to whom correspondence should be addressed.

Academic Editor: Alexander Sasha Krupnick

Front. Biosci. (Elite Ed) 2013, 5(1), 266–272; https://doi.org/10.2741/E614
Published: 1 January 2013
(This article belongs to the Special Issue Recent advances in experimental lung biology)
Abstract

Lung transplantation is a life saving treatment for end stage pulmonary diseases. The development and refinement of this therapy required the utilization of various animal models, without which this procedure would not have become a clinical reality. Canine models were critical in the initial breakthroughs in surgical technique and immunosuppressive regimens, which directly led to the first successful human lung transplantation. Orthotopic lung transplant models in the rat provided a platform for more detailed investigation of immune responses to pulmonary grafts. Investigation of chronic rejection of lungs has significantly been advanced through the use of mouse tracheal transplant experiments. And finally, the advent of orthotopic, vascularized lung transplantation in the mouse opened the door to the use of genetic and molecular tools that are necessary for the rigorous mechanistic study of alloimmune and non- alloimmune factors contributing to lung graft failure. Taken together, animal models will continue to be a cornerstone in the advancement of clinical success in lung transplantation.

Keywords
Lung transplantation
Experimental models
Animal models
Dogs
Rats
Swine
Mice
Heterotopic
Orthotopic
Review
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