IMR Press / FBE / Volume 4 / Issue 6 / DOI: 10.2741/e543

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Bone cells and the mechanisms of bone remodelling

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1 Unita di Medicina Rigenerativa, Ospedale Pediatrico Bambino Gesu, piazza Sant Onofrio 4, 00165 Rome
2 Department of Experimental Medicine, University of L Aquila, via Vetoio Coppito 2, 67100 L’Aquila, Italy

Academic Editor: Ermanno Bonucci

Front. Biosci. (Elite Ed) 2012, 4(6), 2302–2321; https://doi.org/10.2741/e543
Published: 1 January 2012
(This article belongs to the Special Issue The biomineralization process: mechanism, problems, perspectives)
Abstract

Bone is a peculiar connective tissue which functionally interacts with many other organs and tissues, including bone marrow, lymphoid tissue, kidney, adipose tissue, endocrine pancreas, brain and gonads. Bone functions are accomplished by three principal cell types: the osteoblasts, cells of mesenchymal origin having osteogenic functions, the osteoclasts, giant multinucleated cells arising from the monocyte-macrophage line and devoted to resorb bone, and the osteocytes, the latter arising from mature osteoblasts that, once deposited the bone matrix, remain trapped in it, becoming quiescent cells. Osteocytes are known for their role as mechanosensors, however, old and new evidence showed their active contribution to mineral homeostasis. Moreover, the cross-talk between bone cells is crucial, since a correct bone homeostasis relies on a right coupling between osteoblast and osteoclast functions. Any deregulation of this coupling is responsible for bone disease condition, which reflects on other organs with which bone interacts.

Keywords
Osteoblast
Osteoclast
Osteocyte
Bone remodelling
Review
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