IMR Press / FBE / Volume 4 / Issue 5 / DOI: 10.2741/e518

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


The thermoneutral zone: implications for metabolic studies

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1 Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism of Maastricht University Medical Center, Maastricht, The Netherland
2 Department of Mechanical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands

*Author to whom correspondence should be addressed.

Front. Biosci. (Elite Ed) 2012, 4(5), 1975–1985;
Published: 1 January 2012

A thermoneutral environment is important for many human physiological studies. The thermoneutral zone (TNZ) is defined as the range of ambient temperatures without regulatory changes in metabolic heat production or evaporative heat loss. Many factors influence the thermoneutral zone, such as body composition, clothing, energy expenditure, age and gender. These factors have the potential to introduce bias in study results and therefore need to be taken into consideration in many metabolic studies or studies on obesity, medical conditions, thermal comfort or vigilance. Given new developments on the TNZ combined with historical views the aim of this review is to 1) provide insight in how the human TNZ is affected by internal and external factors, 2) indicate how skin blood flow characteristics could be used as an objective criterion for determining whether someone is in the thermoneutral zone, 3) explain implications of the TNZ on metabolic studies and 4) indicate future directions to enhance understanding of the TNZ, especially for the elderly and obese.

Skin blood flow
Body composition
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