IMR Press / FBE / Volume 3 / Issue 1 / DOI: 10.2741/E245

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Efficacy of Cordyceps sinensis in long term treatment of renal transplant patients
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1 Department of Renal Transplantation, Center of Nephropathy, the First Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an, 710061, China

*Author to whom correspondence should be addressed.

Academic Editor: Yong Zhao

Front. Biosci. (Elite Ed) 2011, 3(1), 301–307; https://doi.org/10.2741/E245
Published: 1 January 2011
(This article belongs to the Special Issue Transplant immunology)
Abstract

High doses of cyclosporin A (CsA) can not be used in the long term treatment of kidney allograft recipients primarily due to severe side effects. In the present study, we investigated the potential application of Cordyceps sinensis (CS) in the long term treatment of renal transplant patients. The renal function and survival rates of grafts and patients was not significantly different between the control group and the treatment group. With the exception of those showing acute rejection, the incidence of complications was significantly lower in the treatment group compared with that in the control group. Furthermore, the dosage and the concentration trough of CsA in whole blood were significantly lower in the treatment than control group. However, there was no significant difference in the serum level of IL-2 in the two groups. Interestingly, the serum level of IL-10 in the treatment group was higher than that in control group. These data demonstrat that CS may be
used in combination with a low dose of CsA in the long term treatment of kideny transplant patients.

Keywords
Transplantation
Renal
Cordyceps sinensis
Immunoregulation
Cyclosporine A
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