Amplification of speckle-microscope signal by using gold nanoparticle stable of contents

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Article

Onega V. Ulianova^1,2, Nadejda N. Filonova¹, Sergey S. Ulyanov², Lev A. Dykman³, Olga S. Larionova⁴, Valentina A. Feodorova^1,*

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¹ Federal Research Center for Virology and Microbiology, Branch in Saratov, Saratov, 410028, Russia

² Saratov State University, Saratov, 410012, Russia

³ Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, Saratov, 410049, Russia

⁴ Saratov State Agrarian University, Saratov, 410012, Russia

Send correspondence to: Valentina A. Feodorova, Federal Research Center for Virology and Microbiology, Branch in Saratov, Saratov, 410028, Russia, Tel: 7-8452-200-825, Fax: 7-8452-200-830, E-mail: feodorovav@mail.ru

Front. Biosci. (Elite Ed) 2020, 12(1), 126–138; https://doi.org/10.2741/E862

Published: 1 January 2020

(This article belongs to the Special Issue Global control of infectious disesses)

Abstract

Speckle-microscopy is used for the detection of Chlamydia trachomatis in aqueous suspensions or on slides. Monoclonal antibody tagged with gold nanoparticles that form biospeckles have also been used with a small number of scatterers. By devising a prototype of laser scanning speckle-microscope, we now demonstrate that the signal of speckle microscope can be significantly amplified in the presence of gold nanoparticles. This enhancement of signal emitted from gold nanoparticles offers a better approach to the detection of C. trachomatis.

Keywords

Chlamydia trachomatis

Gold Nanoparticles

Laser

Speckle

Microscopy

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Front. Biosci. (Elite Ed) Print ISSN 1945-0494 Electronic ISSN 1945-0508