IMR Press / JIN / Volume 20 / Issue 2 / DOI: 10.31083/j.jin2002055
Open Access Commentary
Potential protective role of astrocytes in the pathogenesis of astrocyte-mediated synaptic plasticity of Parkinson’s disease
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1 2017 Clinical Excellence and Innovation Class of the Second Clinical Medical College of Southern Medical University, 510515 Guangzhou, Guangdong Province, China
2 Department of Histology and Embryology, School of Basic Sciences, Southern Medical University, 510515 Guangzhou, Guangdong Province, China
*Correspondence: (Kangrong Lu)
J. Integr. Neurosci. 2021, 20(2), 515–525;
Submitted: 3 February 2021 | Revised: 8 March 2021 | Accepted: 22 April 2021 | Published: 30 June 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

Astrocytes are the most abundant glia in the central nervous system that play a significant role in disease. Recently, it roles of synaptic plasticity in neuropathological damages have been questioned whether the structural and functional plasticity of synapses contributes to the pathogenesis of Parkinson’s disease. The regulation of synaptic plasticity by astrocytes has also been widely researched based on astrocytes regulate synaptic plasticity by releasing Adenosine triphosphate, glutamate, and D-serine. We discuss the possible role of astrocytes in the regulation of synaptic plasticity, which may provide a new direction to Parkinson’s disease treatment.

Parkinson's disease (PD)
Synaptic plasticity
Fig. 1.
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