IMR Press / JIN / Volume 19 / Issue 1 / DOI: 10.31083/j.jin.2020.01.1253
Open Access Original Research
Protective effects of medicinal plant breviscapine on postcerebral hemorrhage in rats
Show Less
1 Department of Neurosurgery, The First Affiliated Hospital of Zhejiang Chinese Medical University, No.54, Youdian Road, Shangcheng District, Hangzhou, Zhejiang, 310053, P. R. China
2 Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang Chinese Medical University, No.318, Chaowang Road, Gushu District, Hangzhou, Zhejiang, 310004, P. R. China
*Correspondence: (Xu Li)
These authors contributed equally.
J. Integr. Neurosci. 2020, 19(1), 101–109;
Submitted: 6 December 2019 | Accepted: 3 March 2020 | Published: 30 March 2020
Copyright: © 2020 Chen et al. Published by IMR press.
This is an open access article under the CC BY-NC 4.0 license (

Medicinal plant breviscapine is shown to exhibit a protective role in tissue damage after cerebral hemorrhage. The effects of breviscapine on neurological deficit score, brain tissue water content, brain pathological tissue changes, blood-brain barrier bidirectional regulation, and inflammatory factors after cerebral hemorrhage in rats were observed. Western blot and real-time quantitative polymerase chain reaction were performed to explore how Periostin and nuclear factor kappa-B pathway-related factors protein expression contribute to the protective effects of breviscapine on brain injury. Breviscapine inhalation could reduce neurological deficit scores and brain tissue water content. Hematoxylin-eosin staining showed that breviscapine could improve the pathological changes of brain tissue and alleviate brain damage. Breviscapine reduced the abnormal increase of Evans blue content caused by a cerebral hemorrhage, and could significantly inhibit the levels of inflammatory factors interleukin-6 and tumor necrosis factor-α. Also, breviscapine significantly inhibited the expressions of Periostin and nuclear factor kappa-B pathway-related factors after cerebral hemorrhage, and alleviate brain damage by down-regulating Periostin expression and inhibiting nuclear factor kappa-β signaling pathway.

cerebral hemorrhage
Figure 1.
Back to top