IMR Press / FBL / Volume 6 / Issue 3 / DOI: 10.2741/tatterso

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
CFTR and pseudomonas infections in cystic fibrosis
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1 Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109-0620, USA
2 Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI 48109-0620, U.S.A.

Academic Editor: Jeffrey Cirillo

Front. Biosci. (Landmark Ed) 2001, 6(3), 890–897; https://doi.org/10.2741/tatterso
Published: 1 August 2001
(This article belongs to the Special Issue Bacterial respiratory pathogens)
Abstract

Pseudomonas aeruginosa is a significant threat to human health as it is frequently recalcitrant to conventional antibacterial therapy. This ubiquitous gram-negative bacterium is notorious for its nutritional and ecological flexibility and its resistance to both antibiotic treatments and sanitary measures. These properties contribute to its prominence as a leading source of opportunistic nosocomial (hospital acquired) and a less appreciated, but significant cause of community acquired infections. P. aeruginosa remains a considerable problem for patients with burns, neutropenic individuals, and cystic fibrosis patients (CF). In this review, we will address the current issues in P. aeruginosa infections in CF. A major emphasis will be placed on the factors predisposing CF patients to colonization with P. aeruginosa.

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