Identification of Diagnostic Biomarkers Associated With M1 Macrophage in Lung Squamous Cell Carcinoma via Machine Learning

Huiting Deng, Zhenling Wang, Qiangzhe Zhang

Front. Biosci. (Landmark Ed) 2025, 30(10), 44661; https://doi.org/10.31083/FBL44661

Temporal Orchestration of Immunity: How Circadian Clocks Coordinate Immune Responses

Yunxin Jiang, Chao Liu, Yingbin Zhong

Front. Biosci. (Landmark Ed) 2025, 30(10), 39948; https://doi.org/10.31083/FBL39948

Ionizing Radiation in Clinical Diagnostics and Radiotherapy: The Dual Role of NRF2 in Cell Protection and Carcinogenesis

Alessandra Verdina, Gabriella D’Orazi

Front. Biosci. (Landmark Ed) 2025, 30(10), 39800; https://doi.org/10.31083/FBL39800

(This article belongs to the Special Issue NRF2 and Cancer)

A Comparative Study of the Effects of Nine CXCR3 Antagonists on Macrophage Function and the Treatment of Acute Lung Injury

Mengjie Zhang, Ziyu Wan, Zefeng Zhu, Pengbin Wang, Xuan Xu, Tianhao Ma, Feng Qian, Lexing Li, Guoquan Liu, Wei Gu

Front. Biosci. (Landmark Ed) 2025, 30(10), 45931; https://doi.org/10.31083/FBL45931

Metabolomics Profiling of Kidney, Spleen, Lung, and Liver Tissues in a Mouse Model of Sepsis

Moongi Ji, Byeongchan Choi, Chanho Kim, Jaeyeop Lim, Man-Jeong Paik

Front. Biosci. (Landmark Ed) 2025, 30(10), 45558; https://doi.org/10.31083/FBL45558

Changes of Microglial Cells in the Progression of Neurodegeneration in Natural Prion Disease

Marta Monzón, Juan Sauca Pérez, Rodrigo S. Hernández, Rocío Sarasa, Moisés Garcés, M José Luesma, Juan J Badiola

Front. Biosci. (Landmark Ed) 2025, 30(10), 47074; https://doi.org/10.31083/FBL47074

Genomic Instability is Widespread in Esophageal Squamous Dysplasia and Increases During the Progression to Cancer

Haiyin An, Xian Cheng, Liyan Xue, Guiqi Wang, Xiuli Zhu, Junyi Li, Ting Xiao, Shujun Cheng

Front. Biosci. (Landmark Ed) 2025, 30(10), 41107; https://doi.org/10.31083/FBL41107

Cathepsin S Contributes to Bladder Fibrosis Following Bladder Outlet Obstruction via IL-6 Trans-signaling

Mengchen Yang, Xilei Liu, Hong Wang, Tianyu Shen, Liang Wang

Front. Biosci. (Landmark Ed) 2025, 30(10), 45355; https://doi.org/10.31083/FBL45355

Study on the Mechanism of CCN2 Promoting Sorafenib Resistance in HCC and Its Combined Intervention Strategy

Lei Cui, Junhao Liu, Yongxue Lv, Bendong Chen, Kejun Liu, Yang Bu

Front. Biosci. (Landmark Ed) 2025, 30(10), 45454; https://doi.org/10.31083/FBL45454

Glutamate Excitotoxicity: A Key Secondary Injury Mechanism of Traumatic Brain Injury and Spinal Cord Injury

Jiamei Hou, Kelena Klippel, Prodip Bose

Front. Biosci. (Landmark Ed) 2025, 30(10), 38904; https://doi.org/10.31083/FBL38904

(This article belongs to the Special Issue Exploring Pathomechanisms, Novel Targets, and New Interventions of Neurological and Neuropsychiatric Disorders - Volume 2)

Urinary Metabolomics-Driven Discovery of Metabolic Markers and Molecular Subtyping in Liver Cancer

Hemeng Wu, Hongsheng Lin, Fuli Long, Rongzhen Zhang, Minpeng Li, Yunyong Wang, Faming Shu, Yangwu Zhang, Mingfen Li, Xiaoling Zhou

Front. Biosci. (Landmark Ed) 2025, 30(10), 45438; https://doi.org/10.31083/FBL45438

Beyond Passive Bystander: Glioblastoma-Educated Astrocyte Suppressing T Cell

Yuan-Yuan Wang, Wei-Lin Jin

Front. Biosci. (Landmark Ed) 2025, 30(10), 44810; https://doi.org/10.31083/FBL44810

Targeting Ferroptosis: New Insights and Therapeutic Advances in MAFLD Complicating T2DM

Fang Yao, Gaochao Wang, Fan Ning, Yanbo Shi

Front. Biosci. (Landmark Ed) 2025, 30(10), 39735; https://doi.org/10.31083/FBL39735

BRD4-S Drives Colorectal Cancer Progression via DDX27-Regulated Splicing and MAPK Signaling Activation

Chenlu Wang, Hong Hong, Lining Zhou, Fuying Chu, Xiang Chen

Front. Biosci. (Landmark Ed) 2025, 30(10), 46158; https://doi.org/10.31083/FBL46158

Pharmacological Modulation of NLRP3: From Therapy Personalization to Innovative Drugs

Giulia Zudeh, Sara Sossai, Jacopo Angelini, Gabriele Stocco, Marianna Lucafò

Front. Biosci. (Landmark Ed) 2025, 30(10), 39537; https://doi.org/10.31083/FBL39537

Artificial Intelligence in the Evolution of Interventional Therapy for Liver Cancer: Navigating the Tumor Microenvironment

Zhe Xiu, Wenlong Zeng, Jianyang Guo, Guirong Tu, Xiaopeng Chen, Jianpeng Sheng, Huangxiang Chen

Front. Biosci. (Landmark Ed) 2025, 30(10), 37633; https://doi.org/10.31083/FBL37633

Complete Genome Sequence Analysis of the Bacterial Wilt Disease Pathogen Strain MLY158

Junxian Zou, Guan Lin, Juntao Gao, Denghui Li, Yu Cui, Bin Kong, Konghua Xie, Yong Liu, Xingjiang Chen

Front. Biosci. (Landmark Ed) 2025, 30(10), 46230; https://doi.org/10.31083/FBL46230

Is Regulated by Recursive Splicing and Inhibits Hepatocellular Carcinoma Metastasis by Inhibiting E-Cadherin Protein Degradation

Yuanyuan Guo, Xianghui Fu, Yan Tian

Front. Biosci. (Landmark Ed) 2025, 30(10), 46013; https://doi.org/10.31083/FBL46013

Deciphering the Role of KIF18A in Osteosarcoma Progression: An Integrative Analysis and Experimental Validation

Zhiqian Gu, Songou Zhang, Xudong Hu, Nanjian Xu, Yang Wang, Jian Ruan, Weihu Ma, Hong Chen

Front. Biosci. (Landmark Ed) 2025, 30(10), 44663; https://doi.org/10.31083/FBL44663

SENP5 Attenuates LPS-Induced Acute Lung Injury by Inhibiting Apoptosis of Lung Epithelial Cells Through SLC7A5/mTOR Signaling Pathway

Yiran He, Hai Zhang, Jianmin Gu, Minjie Ju, Chunbing Zhang

Front. Biosci. (Landmark Ed) 2025, 30(10), 45811; https://doi.org/10.31083/FBL45811

HIV-1 Entry Mechanisms: Protein-Host Receptor Interactions and Membrane Fusion Dynamics

Amir Elalouf, Hadas Elalouf, Hanan Maoz

Front. Biosci. (Landmark Ed) 2025, 30(10), 37412; https://doi.org/10.31083/FBL37412

Improves Myocardial Fibrosis in Hypertrophic Cardiomyopathy Through the TGF-β/Smad3 Signal Pathway

Nana Qin, Wenjun Wu, Baoyin Li

Front. Biosci. (Landmark Ed) 2025, 30(10), 45595; https://doi.org/10.31083/FBL45595

Macrophages in Lupus Nephritis: Insights into Its Pathogenesis and Emerging Treatments

Lu Zhang, Jianpeng Sheng, Ting Liu

Front. Biosci. (Landmark Ed) 2025, 30(10), 39365; https://doi.org/10.31083/FBL39365

The Impact of Splicing Factor Mutations on Clonal Hematopoiesis and Myeloid Neoplasm Progression

Takuya Izumi-Tamura, Asuka Kawachi, Akihide Yoshimi

Front. Biosci. (Landmark Ed) 2025, 30(10), 38825; https://doi.org/10.31083/FBL38825

Calcitonin Alleviates Sepsis-Induced Acute Lung Injury by Inhibiting the HMGB1/MyD88/NF-κB Pathway by Targeting CD3D

Hongyan Zhang, Ruiqing Zong, Huiqi Wu, Jun Jiang, Jian He

Front. Biosci. (Landmark Ed) 2025, 30(10), 44677; https://doi.org/10.31083/FBL44677

From Bench to Motion: Unraveling Exercise Biology Through 3D Human Organoids

Limin Xu, Yu Wang, Chenshi Xi, Jingqi Liu, Weijian Xu, Mutong Han, Jiahao Wu, Jianyu Pang, Chong Gao, Lina Sun

Front. Biosci. (Landmark Ed) 2025, 30(10), 40854; https://doi.org/10.31083/FBL40854

An Anoikis-Based Prognostic Signature Identifies MYC as a Key Regulator of Malignancy and Immunotherapy Resistance in Bladder Cancer

Zhen Tang, Jiao Peng, Xiaoyu Pan, Yuefeng Kong, Haisong Lin, Suchun Wei, Yi Zhan, Siping Zeng

Front. Biosci. (Landmark Ed) 2025, 30(10), 45386; https://doi.org/10.31083/FBL45386

Adaptability Beyond Darwin: Microbial Evolution, Mitochondria, and the Thermodynamic Frontiers of Survival

George B. Stefano

Front. Biosci. (Landmark Ed) 2025, 30(10), 45962; https://doi.org/10.31083/FBL45962

Biophysical Properties of the Extracellular Matrix in Cancer: Insights Into Immunotherapy

Xiang Zheng, Famin Ke, Mingxuan Yao, Hanyu Yang, Yufan Luo, Xixu Liu, Cheng Chen, Jiayi Zhang, Xiurong Guo, Can Song, Xiaoyan Liu, Dandan Wang, Qiuyu Liu

Front. Biosci. (Landmark Ed) 2025, 30(10), 44127; https://doi.org/10.31083/FBL44127

is Required for Zebrafish Early Cardiac Development

Yukun Chen, Qiuping Zhang, Xiaoyan Peng, Xinrui Wang, Hua Cao, Qiang Chen, Shuting Huang, Yuqing Lei

Front. Biosci. (Landmark Ed) 2025, 30(10), 44633; https://doi.org/10.31083/FBL44633