Introduction: Cancer is the leading cause of death globally according to WHO in 2020. It is initiated by genetic mutations that occur due to numerous factors. The aim of the review: This review provides a clear view of the potential use of chromosome 6 open reading frame 106 (C6orf106) as a biomarker, based on previous studies. Results: Recent studies have investigated the association of C6orf106 with breast cancer and non-small cell lung cancer and showed that silencing C6orf106 leads to inhibition of malignancy in both diseases, as well as showing a positive correlation between C6orf106 expression and malignancy. Other studies demonstrated the interaction of C6orf106 with other malignancy factors that play a role in many cancer types, such as cyclin A2, cyclin B1, N-cadherin, E-cadherin, c-MYC, p120ctn, and vimentin. These factors play a significant role in cellular adhesion and the regulation of the cell cycle. C6orf106 is a potential target for numerous cancers, not only non-small cell lung cancer and breast cancer. In conclusion: understanding the connection of C6orf106 with crucial malignancy factors makes it clear that C6orf106 is a potential therapeutic target and diagnostic biomarker for many disease cancer.
Cite this article
Volume | Year
Open Access Review
Association of chromosome 6 open reading frame 106 in different cancers
1 Department of Biorepository Biomedical Research Administration, Research Center, King Fahad Medical City, 12231 Riyadh, Saudi Arabia
2 Faculty of Medicine, Imam Abdulrahman Bin Faisal University, 34212 Dammam, Saudi Arabia
3 Department of Scientific Writing Research Services Administration, Research Center, King Fahad Medical City, 12231 Riyadh, Saudi Arabia
4 Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Centre, 11564 Jeddah, Saudi Arabia
*Correspondence: firstname.lastname@example.org (Saeed Baradwan)
Front. Biosci. (Landmark Ed) 2021, 26(8), 360–369; https://doi.org/10.52586/4949
Submitted: 28 May 2021 | Revised: 22 July 2021 | Accepted: 23 July 2021 | Published: 30 August 2021
Copyright: © 2021 The Author(s). Published by BRI.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Chromosome 6 open reading frame 106