Background: Mitochondrial dysfunction plays a crucial role in Parkinson’s disease (PD) pathogenesis. The present study was undertaken to investigate the effects of Telmisartan (TEL), an angiotensin II type 1 receptor (AT1R) blocker, on the mitochondria-specific genes expression in a mouse model of Parkinsonism.
Materials and methods: Mice were divided into 5 groups with 6 in each; Group I received 0.5% CMC (control) + saline, Group II received 0.5% CMC + 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (positive control), Group III & IV received MPTP + TEL 3 and 10 mg/kg, p.o. respectively, Group V received TEL 10 mg/kg, p.o. (drug control). MPTP was given 80 mg/kg intraperitoneal in two divided doses (40 mg/kg
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Effects of Telmisartan, an AT1 receptor antagonist, on mitochondria-specific genes expression in a mouse MPTP model of Parkinsonism
Bipul Ray1,2, Girish Ramesh3, Sudhir Rama Verma4,5, Srinivasan Ramamurthy6, Sunanda Tuladhar1,2, Arehally Marappa Mahalakshmi1, Musthafa Mohamed Essa7,8,*, Saravana Babu Chidambaram1,2,*
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1
Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, 570015 Mysuru, India
2
Centre for Experimental Pharmacology and Toxicology, Central Animal Facility, JSS Academy of Higher Education & Research, 570015 Mysuru, India
3
Molecular Biophysics, Saarland University, 66123 Saarland, Germany
4
Department of Clinical Sciences, College of Dentistry, Ajman University, 346 Ajman, UAE
5
Center of Medical and Bio-allied Health Sciences Research, Ajman University, 346 Ajman, UAE
6
College of Pharmacy & Health Sciences, University of Science and Technology of Fujairah, 2202 Fujairah, UAE
7
Department of Food Science and Nutrition, CAMS, Sultan Qaboos University, 123 Muscat, Oman
8
Aging and Dementia Research Group, Sultan Qaboos University, 123 Muscat, Oman
*Correspondence: babupublications@gmail.com (Saravana Babu Chidambaram); drmdessa@gmail.com (Musthafa Mohamed Essa)
Front. Biosci. (Landmark Ed) 2021, 26(8), 262–271;
https://doi.org/10.52586/4942
Submitted: 21 February 2021 | Accepted: 14 April 2021 | Published: 30 August 2021
Copyright: © 2021 The Author(s). Published by BRI.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Keywords
Parkinson’s disease
Telmisartan
Mitochondria
PINK1
Parkin
DJ-1
LRRK2
MTA1
UCHL1
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