IMR Press / FBL / Volume 26 / Issue 5 / DOI: 10.52586/4925
Open Access Review
UPF1: a potential biomarker in human cancers
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1 Department of Gastrointestinal Surgery, the First Affiliated Hospital of Shantou University Medical College, 515041 Shantou, China
2 Shantou University Medical College, 515041 Shantou, Guangdong, China
*Correspondence: (Yong-Ming Zeng)
Front. Biosci. (Landmark Ed) 2021, 26(5), 76–84;
Submitted: 19 October 2020 | Accepted: 28 January 2021 | Published: 30 April 2021
Copyright: © 2021 The Author(s). Published by BRI.
This is an open access article under the CC BY 4.0 license (

Recently, Up-frameshift protein 1 (UPF1) is reported to be downregulated in various cancers and its low expression is closely correlated with poor prognosis. UPF1 is well known as a master regulator of nonsense-mediated mRNA decay (NMD), which serves as a highly conserved mRNA surveillance process protecting cells from aberrant toxic transcripts. Due to dysfunction of UPF1, NMD fails to proceed, which contributes to tumor initiation and progression. This review shows a brief summary of the aberrant expression, functional roles and molecular mechanisms of UPF1 during tumorigenesis. Increasing evidence has indicated that UPF1 could serve as a potential biomarker for cancer diagnosis and treatment for future clinical applications in cancer.

Human cancers
Fig. 1.
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