IMR Press / FBL / Volume 25 / Issue 1 / DOI: 10.2741/4794

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Reporting on the future of integrative structural biology ORAU workshop
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1 Department of Physics and Astronomy, 118 Kinard Laboratory, Clemson University, Clemson, SC 29631
2 Department of Biological Sciences, 132 Long Hall, Clemson University, Clemson, SC 29631
3 Eukaryotic Pathogen Innovations Center, Life Sciences Building, Clemson University, Clemson, SC 29631
Send correspondence to: Hugo Sanabria, Physics and Astronomy, Clemson University, 214 Kinard Lab, Clemson, S.C. 29634-0978, Tel: 864-656-1749, Fax: 864-656-0805, E-mail: hsanabr@clemson.edu
Front. Biosci. (Landmark Ed) 2020, 25(1), 43–68; https://doi.org/10.2741/4794
Published: 1 January 2020
Abstract

Integrative and hybrid methods have the potential to bridge long-standing knowledge gaps in structural biology. These methods will have a prominent role in the future of the field as we make advances toward a complete, unified representation of biology that spans the molecular and cellular scales. The Department of Physics and Astronomy at Clemson University hosted The Future of Integrative Structural Biology workshop on April 29, 2017 and partially sponsored by partially sponsored by a program of the Oak Ridge Associated Universities (ORAU). The workshop brought experts from multiple structural biology disciplines together to discuss near-term steps toward the goal of a molecular atlas of the cell. The discussion focused on the types of structural data that should be represented, how this data should be represented, and how the time domain might be incorporated into such an atlas. The consensus was that an explorable, map-like Virtual Cell, containing both spatial and temporal data bridging the atomic and cellular length scales obtained by multiple experimental methods, represents the best path toward a complete atlas of the cell.

Keywords
Integrative Methods
Hybrid Methods
Structural Biology
Workshop
Review
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