Research of Patients with Peripheral Arterial Disease

Dear Colleagues,

Peripheral arterial disease (PAD) is a clinical condition characterized by a decreased perfusion of a lower extremity and is associated with a high risk for worse outcomes such as chronic limb-threatening ischemia, cardiovascular events (i.e. myocardial infarction and stroke) and all-cause mortality. The onset of PAD is also a marker of systemic vascular dysfunction, being associated with multiple comorbidities including chronic kidney disease (CKD). CKD forecasts a 2 to 4 times increased risk for the onset of PAD. Both conditions are characterized by a dysregulation of extracellular matrix deposition due to imbalances in metalloproteinases, chronic inflammation and increased release of cytokines. Moreover, the association of CKD and PAD is associated with an increased risk for future morbities. Proper and early treatment of CKD may reduce the onset of PAD and overall improve individual prognosis. Concomitantly, future studies on biomarkers of CKD and PAD may help further the comprehension of pathogenesis of the disease and the detection of patients at very high risk of future cardiovascular events. The aim of this special issue is to collect recent research evidence around PAD in the specific setting of CKD. Original articles (both observational and randomized studies), review articles, meta-analyses, and case series are potentially suitable for this Special Issue.

Dr. Michele Provenzano, Dr. Giuseppe Coppolino and Dr. Claudia Torino

Guest Editors

Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2200 USD. Submitted manuscripts should be well formatted in good English.