IMR Press / RCM / Special Issues / functional_and_metabolic

Functional and Metabolic Correlates of Coronary Disease and Heart Failure

Submission deadline: 30 August 2022
Special Issue Editor
  • Gabriele Fragasso, MD
    Heart Failure Unit, IRCCS San Raffaele University Hospital, Milan, Italy
    Interests: heart failure; left ventricular function; exercise; coronary artery disease; metabolism
Special Issue Information

Dear Colleagues,

Metabolic derangements have long been recognized as playing an important role in the pathophysiology of coronary disease and heart failure. In these conditions, metabolic impairment is not just a feature of the heart, but rather a global issue with important contributions from organs and peripheral tissues. In particular, diabetes mellitus doubles the cardiovascular death rate in patients with coronary artery disease and heart failure, compared to non-diabetic patients. Accelerated atherogenesis mediated by altered cellular metabolism is the likely cause of this association. In fact, ischemic metabolic changes that occur as a consequence of the mismatch between blood supply and cardiac metabolic requirements are heightened by the metabolic changes inherent to diabetes itself. Increased utilization of free fatty acid and the reduced utilization of glucose as source of energy during stress and ischemia are responsible for the increased susceptibility of the diabetic heart to myocardial ischemia and to a greater decrease of myocardial performance for given amounts of ischemia compared to non-diabetic hearts. 

From a general point of view, the cardiac ability to oxidize nutrients critical to cardiac contraction is diminished in these pathological conditions, making the heart energy depleted. In this context, therapeutic approaches aimed at improving cardiac metabolism through manipulations of the utilization of metabolic substrates should help offset myocardial ischemia and heart failure. Specific metabolic drugs have been shown to improve global cardiac metabolism and, consequently, to increase cardiac resistance to ischemia and to reduce the decline of left ventricular function due to chronic under-perfusion and repetitive episodes of myocardial ischemia. Therefore, modulation of myocardial metabolism should represent a key target in patients with coronary artery disease and heart failure. 

In this special issue of Reviews in Cardiovascular Medicine, the functional and metabolic correlates of coronary disease and heart failure will be analyzed from different angles. The aim is to disseminate in the cardiological/internal medicine audience the important, but often neglected, concept of metabolic derangement as a major contributing factor to the pathophysiology of these diseases.

Dr. Gabriele Fragasso

Guest Editor

coronary disease
heart failure
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2200 USD. Submitted manuscripts should be well formatted in good English.

Planned Paper (3 Papers)
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to IMR Press journals will subject to peer-review before acceptance

Mechanisms of Cardiac Energy Metabolism Derangement in Ischemic Heart Disease and Heart Failure

Gary David Lopaschuk

Metabolic Management of Coronary Artery Disease in Diabetic Coronary Patients

Giuseppe Rosano

Old and New Directions in the Treatment of Heart Failure: Targeting Myocardial Metabolism

Fragasso Gabriele

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