IMR Press / RCM / Volume 23 / Issue 5 / DOI: 10.31083/j.rcm2305167
Open Access Review
Importance of Autophagy in Mediating Cellular Responses to Iron Overload in Cardiomyocytes
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1 Department of Biology, York University, Toronto, ON M3J 1P3, Canada
*Correspondence: (Gary Sweeney)
Academic Editors: Morris Karmazyn and Jan Slezak
Rev. Cardiovasc. Med. 2022, 23(5), 167;
Submitted: 31 January 2022 | Revised: 7 March 2022 | Accepted: 21 March 2022 | Published: 7 May 2022
(This article belongs to the Special Issue Highlighting Excellence in Cardiovascular Research in Canada)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Both iron overload and deficiency can promote development of cardiomyopathy. Advances in our knowledge from recent research have indicated numerous potential cellular mechanisms. Regulation of myocardial autophagy by iron is of particular interest and will be reviewed here. Autophagy is already well established to play a significant role in regulating the development of heart failure. This review will focus on regulation of autophagy by iron, crosstalk between autophagy and other cellular process which have also already been implicated in heart failure (oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, ferroptosis) and the therapeutic potential of targeting these interactions.

iron overload
oxidative stress
endoplasmic reticulum stress
Fig. 1.
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