IMR Press / RCM / Volume 23 / Issue 2 / DOI: 10.31083/j.rcm2302071
Open Access Review
Mechanical circulatory support in acute myocardial infarction complicated by cardiogenic shock
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1 Department of Cardiology, Freeman Hospital, NE7 7DN Newcastle upon Tyne, UK
2 Cardiology Department,Henry Ford Hospital, Detroit, MI 48202, USA
3 Cardiovascular Medicine Department, Faculty of Medicine, Tanta University, 31527 Gharbia Governorate, Egypt
4 Translational and Clinical Research Institute, Newcastle University, NE1 7RU Newcastle, UK
*Correspondence: (Mohammad Alkhalil)
Academic Editors: John Elefteriades and Bulat Ziganshin
Rev. Cardiovasc. Med. 2022, 23(2), 71;
Submitted: 30 August 2021 | Revised: 27 October 2021 | Accepted: 27 October 2021 | Published: 21 February 2022
(This article belongs to the Special Issue Interventions for the failing left ventricle)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Patients with acute myocardial infarction (MI) complicated by cardiogenic shock (CS) have poor prognosis. Over the last two decades, there has been some improvement in mortality rates associated with CS. Initial measures to stabilise patients should follow a shock protocol, including therapies such as volume expansion, inotropes/vasopressors, and early coronary revascularisation. The use of mechanical circulatory support (MCS) devices demonstrated better haemodynamic and metabolic profiles for patients with CS. However, these benefits have not been consistently translated into significant reductions in cardiovascular adverse events. This review aims to discuss emerging concepts related to CS including an update on its classification and pathophysiology. The focus is on recent evidence regarding the use of MCS and the timing of initiating in patients with CS.

Cardiogenic shock
Fig. 1.
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