Epilepsy is a brain disorder characterized by spontaneous recurrent seizures and high rates of comorbid health conditions. It affects about 50 million people worldwide and hence the prevention or modification of epilepsy in patients at risk is a major unmet medical need. The chronic phase of the disease is typically preceded by a latent period that is free of clinical seizures. During this period, complex processes transform the healthy brain into a seizure-prone brain (epileptogenesis). In recent years, many breakthroughs have been made in identifying the cellular and molecular alterations linked to epilepsy, including neurodegeneration, neuroinflammation, loss of BBB integrity, and dysregulation of neurotransmitters. All of these alterations are suspected of being involved in epileptogenesis. However, a better understanding of these processes will help in the discovery of novel therapeutic targets and/or biomarkers to identify patients at risk of developing epilepsy.
This special issue “Cellular and molecular mechanisms in Epilepsy” aims to collect research papers, short communications and systematic reviews covering various aspects of epileptogenesis and epilepsy. Studies on novel treatment and clinical studies are also welcome.
Dr. Pablo Bascunana Almarcha
Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2200 USD. Submitted manuscripts should be well formatted in good English.
- Open Access Original ResearchA Single High Dose of Flufenamic Acid in Rats does not Reduce the Damage Associated with the Rat Lithium-Pilocarpine Model of Status Epilepticus but Leads to Deleterious OutcomesNira Hernández-Martín, Francisca Gomez, Ágata Silván, Rubén Fernández de la Rosa, ... Luis García-GarcíaJ. Integr. Neurosci. 2023, 22(3), 75; https://doi.org/10.31083/j.jin2203075(This article belongs to the Special Issue Cellular and Molecular Mechanisms in Epilepsy)12Downloads71Views