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§Current address: Department of Anesthesiology, University of California San Diego, La Jolla, CA 92093, USA.
Background: Pannexin1 (Panx1) is a membrane channel expressed in
different cells of the nervous system and is involved in several pathological
conditions, including pain and inflammation. At the central nervous system, the
role of Panx1 is already well-established. However, in the periphery, there is a
lack of information regarding the participation of Panx1 in neuronal
sensitization. The dorsal root ganglion (DRG) is a critical structure for pain
processing and modulation. For this reason, understanding the molecular mechanism
in the DRG associated with neuronal hypersensitivity has become highly relevant
to discovering new possibilities for pain treatment. Here, we aimed to
investigate the role of Panx1 in acute nociception and peripheral inflammatory
and neuropathic pain by using two different approaches. Methods: Rats
were treated with a selective Panx1 blocker peptide (