Background: Single-nucleotide polymorphisms (SNPs) in the proprotein
convertase subtilisin/kexin type 9 (PCSK9) gene are known to be
associated with susceptibility to several cerebrovascular diseases, including
ischemic stroke (IS). The aims of this study was to evaluate associations between
PCSK9 gene polymorphisms and the risk of IS. Based on previous reports
linking PCSK9 SNPs to plasma lipid levels and to atherosclerosis, and to
inconsistencies in the reported associations between the SNPs, plasma lipid
levels and IS risk, we choose the PCSK9 rs505151, rs529787, and
rs17111503 to performe the association analysis. Methods: Using multiple
databases, all relevant case-control and cohort studies that matched our search
criteria were collected. Quality assessment of included studies was performed
using the Newcastle-Ottawa Scale. Demographic and genotype data were extracted
from each study, and meta-analysis was performed using Stata/MP 17.0. Odds ratios
(ORs) with 95% confidence intervals (CIs) were calculated using fixed and random
effects models. Results: A critical evaluation was conducted on ten
case-control studies, involving a total of 2426 cases and 2424 controls. Pooled
results from the allelic models indicated the PCSK9 rs505151 G allele
(OR: 1.41, 95% CI: 1.06–1.87, p = 0.019, I
Announcements
Open Access
Systematic Review
The Impact of PCSK9 Gene Polymorphisms on Ischemic Stroke: A Systematic Review and Meta-Analysis
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1
Department of Neurology, Shanxi Cardiovascular Hospital, 030024 Taiyuan, Shanxi, China
2
Department of First Clinical Medical School, Shanxi Medical University, 030001 Taiyuan, Shanxi, China
3
Department of Endocrinology, The First Hospital of Shanxi Medical University, 030001 Taiyuan, Shanxi, China
*Correspondence: weironglee@163.com (Weirong Li)
J. Integr. Neurosci. 2024, 23(3), 62;
https://doi.org/10.31083/j.jin2303062
Submitted: 19 September 2023 | Revised: 10 November 2023 | Accepted: 22 November 2023 | Published: 20 March 2024
Copyright: © 2024 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
Keywords
proprotein convertase subtilisin/kexin type 9
PCSK9
polymorphisms
ischemic stroke
meta-analysis
Funding
201903D321127/Shanxi Provincial Key Research and Development Project
201903D321048/Shanxi Provincial Key Research and Development Project
Figures
Fig. 1.