IMR Press / JIN / Volume 22 / Issue 5 / DOI: 10.31083/j.jin2205129
Open Access Review
The Role of Pyroptosis in Alzheimer's Disease
Show Less
1 Department of Neurology, China-Japan Union Hospital of Jilin University, 130031 Changchun, Jilin, China
2 Engineering Laboratory of Memory and Cognitive Impairment Disease in Jilin Province, 130031 Changchun, Jilin, China
3 Department of Neurosurgery, China-Japan Union Hospital of Jilin University, 130031 Changchun, Jilin, China
*Correspondence: (Qing Zhao)
J. Integr. Neurosci. 2023, 22(5), 129;
Submitted: 8 February 2023 | Revised: 8 March 2023 | Accepted: 16 March 2023 | Published: 22 August 2023
(This article belongs to the Special Issue Cognitive Impairment, Dementia and Alzheimer's Disease)
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Pyroptosis is a type of regulated cell death that relies on caspases, vesicles, and the cleavage of gasdermin proteins (which create pores in the cell membrane). The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome, which is involved in this process, is the most widely studied inflammasome. Caspase-1 activates pro-inflammatory cytokines, such as IL-1β and IL-18. Gasdermin D (GSDMD) is the most important executive protein. GSDMD, a substrate rather than an upstream protease, determines the occurrence of pyroptosis. Pyroptosis is essential for maintaining body homeostasis, but excessive or poorly regulated cell death can aggravate the inflammatory response. Undoubtedly, this will be an important direction for future research on Alzheimer’s disease (AD). Here, we review recent research progress on the morphological characteristics, molecular mechanisms, and role of pyroptosis in the context of AD, thereby providing new directions for identifying potential disease biomarkers and treatment strategies for AD.

Alzheimer's disease
gasdermin D
20200404076YY/Fund of Science and Technology Development Project of Jilin Province
Fig. 1.
Back to top