IMR Press / FBS / Volume 4 / Issue 2 / DOI: 10.2741/s284

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Endosomal trafficking in animal cytokinesis

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1 Molecular Cell Biology Laboratory, Department of Biochemistry, BioSciences Institute, University College Cork, Cork, Ireland
Academic Editor:Crislyn D Souza-Schorey
Front. Biosci. (Schol Ed) 2012, 4(2), 547–555; https://doi.org/10.2741/s284
Published: 1 January 2012
(This article belongs to the Special Issue Membrane trafficking and disease)
Abstract

Cytokinesis is the terminal stage of eukaryotic cell division in which the cytoplasm of a dividing cell is partitioned between two daughter cells. In animal cells, this multifaceted cellular process is spatially and temporally regulated and requires dramatic remodeling of the cytoskeleton and plasma membrane. Animal cytokinesis proceeds when the acto-myosin contractile-ring, formed at the equatorial cortex of a dividing cell, advances inward like a ‘purse string’ and is a major driving-force for the separation of the two daughter cells. In this review, we highlight many of the recent advances in our understanding of the function and mechanisms of action of the endocytic protein machinery that control animal cytokinesis. This includes regulation of endosome delivery and targeting by Rab and ARF GTPases, their effectors FIP3, FIP4 and JIP4, the exocyst and centralsplindlin complexes and phosphoinositides. Roles for endosomal SNAREs, BRUCE and the ESCRT pathway in the membrane remodeling processes that lead to abscission are also discussed.

Keywords
Cytokinesis
endosomes
Rab GTPase
Rab11
ARF6
FIP3
BRUCE
ESCRT
TSG101
Exocyst
Centralsplindlin
phosphoinositide
Review
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