IMR Press / FBS / Volume 16 / Issue 1 / DOI: 10.31083/j.fbs1601008
Open Access Review
The Significance of Lipoproteins in the Development of Obesity
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1 Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia
2 Immanuel Kant Baltic Federal University, 236016 Kaliningrad, Russia
*Correspondence: (Alexander Blagov); (Alexander Orekhov)
Front. Biosci. (Schol Ed) 2024, 16(1), 8;
Submitted: 1 December 2023 | Revised: 25 December 2023 | Accepted: 15 January 2024 | Published: 18 March 2024
Copyright: © 2024 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Disruption of lipoprotein metabolism plays an important role in the development of several cardiovascular, inflammatory, and metabolic diseases. This review examines the importance of different types of lipoproteins and the role they play in the development of dyslipidemia in obesity. The causes and consequences associated with the disruption of lipid metabolism and its significance in the pathogenesis of obesity are considered. The relationship between such pathological processes, which occur alongside obesity as dyslipidemia and inflammation, is determined. In view of the current efficacy and toxicity limitations of currently approved drugs, natural compounds as potential therapeutic agents in the treatment of obesity are considered in the review. The complex mechanisms of lipid metabolism normalization in obesity found for these compounds can serve as one of the confirmations of their potential efficacy in treating obesity. Nanoparticles can serve as carriers for the considered drugs, which can improve their pharmacokinetic properties.

low density lipoproteins (LDL)
22-65-00005/Russian Science Foundation
Fig. 1.
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