Dear Colleagues,
Despite the most recent developments in treatment, childhood cancer still carries an unacceptable burden of death rate. While the prognosis for many pediatric neoplasms has greatly improved over the last decades, for soft tissue and bone sarcomas and other rare tumors, the survival rate is still low. This is especially true for certain histological types, challenging sites of disease and metastatic spread. In such cases, high-dose chemotherapy, demolitive surgery and radiotherapy have been deployed to determine lifelong toxicities and sequelae, yet significant increase in survival rate has not been achieved. Therefore, we are in urgent need of new antineoplastic agents active against sarcomas and other rare tumors. Modern cancer research aims to examine the mechanisms and molecular definition of various pediatric tumor histology types to better identify subtypes and prognostic characteristics of tumor cells of each patient. Most importantly, molecular specificity has allowed the development of antineoplastic agents capable of targeting the tumor cells. Many of these drugs are already utilized in various tumor types; thus far, however, for soft tissue and bone sarcomas, no target therapy agent has demonstrated superiority to standard antineoplastic treatment. The aim of this special issue is to highlight research advances and new treatment strategies for sarcomas and rare tumors in children.
Prof.
Dr. Antonio Ruggiero and Prof.
Dr. Stefano Mastrangelo
Guest Editors
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