IMR Press / FBL / Special Issues / 1463693096243318785

Dynamic Diseases: Mathematical Informed Expert and Knowledge Computing Technology-based Computational Medicine in Complex Systems

Submission deadline: 01 December 2024
Special Issue Editors
  • Yeliz Karaca, MD
    University of Massachusetts Chan Medical School, Worcester, MA, USA
    Interests: Computational methods; Complex systems; Computational complexity; Fractals; Multifractal methods; Fractional methods and their applications; Wavelets and entropy along with their applications; Mathematical neuroscience and biology as well as advanced data analysis in medicine and related domains
  • Dumitru Baleanu, MD
    Çankaya University, Ankara, Turkey and Institute of Space Sciences, Magurele-Bucharest, Romania
    Interests: Fractional dynamics and its applications in science and engineering; Fractional differential equations; Discrete mathematics; Mathematical physics; Mathematical biology; Computational complexity; Soliton theory; Lie symmetry; Dynamic systems on time scales and the wavelet method and its applications
  • Yu-Dong Zhang, MD
    School of Informatics, University of Leicester, Leicester, UK
    Interests: Deep learning and medical image analysis; Convolutional neural networks; Graph convolutional networks; Attention networks; Explainable AI; Advanced AI applications; Medical image analysis; Bio-Inspired computing; Pattern recognition; Transfer learning and medical sensors
  • Majaz Moonis, MD
    Department of Neurology and Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA
    Interests: Stroke outcomes; Its impact in improving stroke and dementia outcomes; Automatic detection of AF for a wristwatch (CoPI), and interactions between stroke and dementia with emphasis on machine learning algorithms
  • Osvaldo Gervasi, MD
    Department of Mathematics and Computer Science, University of Perugia, Via Vanvitelli, Perugia, Italy
    Interests: Parallel and distributed systems; Computational science; Virtual and augmented reality; Artificial intelligence; Free and libre open-source software
  • Khan Muhammad, MD
    Department of Software, Visual Analytics for Knowledge Laboratory, Sejong University, Seoul, Republic of Korea
    Interests: Medical image analysis (brain MRI; diagnostic hysteroscopy and wireless capsule endoscopy); Information security (steganography, encryption, watermarking and image hashing); Video summarization; Computer vision; Fire/smoke scene analysis; IoT (Internet of medical things; Internet of multimedia things) and video surveillance
Special Issue Information

Dear Colleagues,

Dynamic diseases are characterized by striking changes in the dynamic aspects of bodily functions, which require molecular and cellular medical aspects to understand the etiology of them and develop the right treatments in a life-saving and life quality maintaining way by addressing basic biological mechanisms and technologies timely. They also entail a computational medicine-based integrative approach directed at the analysis of underlying parameters in ambiguous conditions. Computational methodologies and mathematical modeling currently play an increasing role in the investigation of mechanisms that are central to the diagnosis, prognosis, prediction and treatment of dynamic human diseases. These progressive and transformative processes have given rise to computational medicine, which uses advanced mathematical, engineering, computational and simulation-related approaches to model the human body as a complex system that ranges from molecules, cells and tissues to the organs of the entire body. Computational medicine also allows the generation of models based on theory and knowledge that are able to capture singular and individual properties concerning health and disease with the aim of accurate decision-making.

Equifinality posits that multiple paths are directed at and linked to a common end state with the overarching aim of unifying sciences. It is critical in computational medicine and its management, which lies at the interface of computational modeling and medicine. This integration enables individualization and personalization of medical decision making to enhance health outcomes, while at the same time limiting the burden on healthcare. To attain this goal, dynamic precision medicine or personalized medicine, including the tailoring of treatment to each patient’s individual characteristics, focuses on giving the right treatment to the patient at the right time. Hence, anticipation, control and management of the complexity of unexpected events can be achieved based on detailed information obtained from conventional biomarkers, genetic cues, and phenotypic and/or psychosocial characteristics. These are critical for distinguishing amongst patients who display similar clinical features within a sub-group.

Health is considered to be a multidimensional, complex, and adaptive state arising from a myriad of non-linear interactions across micro-, macro- and nano-level variables and a biological blueprint. It extends over a broad spectrum of diseases including neurological and biological diseases, as well as cancer, epidemics, vascular disorders, medical oncology, mental disorders, immune-system disorders and virological problems, amongst many others. Accordingly, the preliminary aim of this special issue is the integration of progressive computational medicine and related disciplines with an orientation towards molecular and cellular elements so that accuracy and timely intervention within such hierarchically layered complex systems can be attained. To address the intricate problems that emerge in dynamic diseases, it is important to develop systems in conjunction with advanced mathematical algorithms that touch on chaos, fractals, multifractional, fractional calculus, machine learning and artificial intelligence amongst others. Through such cross-domain understanding, we anticipate this Special Issue will open up new frontiers in which clinical knowledge and computational methodologies act as a unifying framework to promote further research and development of theories and applications, as well as to serve human health at large.

Potential topics of the special issue include but are not limited to:
- Computational diagnostics
- Computational imaging and simulation technologies in biomedicine
- Computational molecular medicine
- Data analytics-based models
- Dynamic precision medicine
- Advanced medical image/signal processing in molecular and cellular research 
- Molecular genetics and epigenetics
- Integrative machine-learning and molecular virology / immunology
- Computational modeling of molecular / cellular complex systems
- Learning-based models in medical imaging (MRI, EEG, X-rays, etc.)
- AI applications in medicine
- Neural systems mimicking neural functioning
- Neural information processing for biological and cellular systems
- Fractals and multifractal methods in dynamic diseases
- Fractional calculus in complex dynamic diseases
- Fractional computing systems
- Non-invasive assessment of disabilities with cellular and molecular orientation 
- Fractional dynamic processes in dynamic diseases
- Personalization in practice: dynamic computational modeling
- Computational imaging and simulation technologies in biomedicine

Assis. Prof. Yeliz Karaca, Prof. Dumitru Baleanu, Prof. Yu-Dong Zhang, Prof. Majaz Moonis, Prof. Osvaldo Gervasi, and Assis. Prof. Khan Muhammad
Guest Editors

Dynamic diseases
Computational medicine
Mathematics-Informed medicine
Algorithmic computation
Data analytics-based models
Dynamic precision medicine
AI for healthcare
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.

Published Paper (2 Papers)
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