IMR Press / FBL / Volume 9 / Issue 3 / DOI: 10.2741/1392

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Multiple functions of maspin in tumor progression and mouse development
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1 Baylor College of Medicine, Department of Molecular & Cellular Biology, Houston, TX 77030
Academic Editor:Philip Patston
Front. Biosci. (Landmark Ed) 2004, 9(3), 2218–2226; https://doi.org/10.2741/1392
Published: 1 September 2004
(This article belongs to the Special Issue Serpins in biology and medicine)
Abstract

Maspin is a unique serpin with diverse biological functions. Initially identified from human normal mammary epithelial cells, maspin expression is either reduced or completely silenced in breast cancers. Numerous studies have implicated maspin function in cancer progression and angiogenesis. Maspin has also been targeted for breast cancer gene therapy. Recently, transgenic and gene knockout mouse models have been used by our laboratory to identify the biological functions of maspin in vivo. In this review, we summarize the multiple functions of maspin in tumor progression and mouse development. These data demonstrate that maspin not only plays a role in tumor progression and metastasis but also is a key regulatory molecule for normal mammary gland and embryonic development.

Keywords
Maspin
Serpin
Tumor progression
Metastasis
Mouse development
Review
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