IMR Press / FBL / Volume 9 / Issue 3 / DOI: 10.2741/1387

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Building a functional artery: issues from the perspective of mechanics
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1 Department of Biomedical Engineering and M.E. DeBakey Institute, Texas A&M University, College Station, TX 77843-3120, USA
Academic Editor:Shu Liu
Front. Biosci. (Landmark Ed) 2004, 9(3), 2045–2055; https://doi.org/10.2741/1387
Published: 1 September 2004
(This article belongs to the Special Issue Molecular and biomechanical bases of vascular tissue engineering)
Abstract

Despite the many successes of arterial tissue engineering, clinically viable implants may be a decade or more away. Fortunately, there is much more that we can learn from native vessels with regard to designing for optimal structure, function, and properties. Herein, we examine recent observations in vascular biology from the perspective of nonlinear mechanics. Moreover, we use a constrained mixture model to study potential contributions of individual wall constituents. In both cases, the unique biological and mechanical roles of elastin come to the forefront, especially its role in generating and modulating residual stress within the wall, which appears to be key to multiple growth and remodeling responses.

Keywords
Vascular tissue engineering
Vascular mechanics
Growth and remodeling
Stress
Elastin
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