IMR Press / FBL / Volume 9 / Issue 1 / DOI: 10.2741/1201

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Gene regulation by song in the auditory telencephalon of songbirds
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1 Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
Academic Editor:John Leah
Front. Biosci. (Landmark Ed) 2004, 9(1), 63–73; https://doi.org/10.2741/1201
Published: 1 January 2004
(This article belongs to the Special Issue Regulation of gene expression in the brain)
Abstract

Inducible gene expression analysis has been successfully used to identify and characterize areas involved in the auditory processing of song in songbirds. When songbirds hear song, zenk, a gene encoding a transcriptional regulator linked to synaptic plasticity, is rapidly and transiently induced in several discrete areas of the telencephalon. This phenomenon is most marked in the caudomedial neostriatum (NCM), a major auditory processing area. zenk induction by song has proven very useful to investigate the functional organization of NCM as well as to characterize song-responding neurons in this brain area. Combined with data from anatomical and electrophysiological studies, the results of gene expression analysis suggest that NCM is involved in the auditory processing of complex sounds such as song and possibly in the formation and/or storage of song auditory memories. Thus, NCM appears to play a prominent role in perceptual aspects of vocal communication, and potentially in the process of vocal learning in songbirds and other vocal learning avian orders, i.e. parrots and hummingbirds.

Keywords
Neuronal Plasticity
Learning
Zebra Finch
Canary
Birdsong
Auditory
zenk
zif-268
egr-1
In Situ Hybridization
Immunocytochemistry
Review
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