Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
In recent years it has become apparent that the hemostatic system has a role to play in regulating angiogenesis. This is achieved by components of the coagulation and fibrinolytic systems regulating proteolysis in the milieu and context of extra cellular matrix and the fibrin clot. It is also an emerging paradigm that cryptic fragments, released by proteolysis from components of the coagulation and fibrinolytic systems, have a role to play in regulating angiogenesis. Presented herein is a brief overview of the regulation of angiogenesis by the hemostatic system.