IMR Press / FBL / Volume 8 / Issue 4 / DOI: 10.2741/1006

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Neural cell adhesion molecules – brain glue and much more!

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1 Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 4809-0616, USA

Academic Editor: Michael Hortsch

Front. Biosci. (Landmark Ed) 2003, 8(4), 357–359;
Published: 1 January 2003
(This article belongs to the Special Issue Neural cell adhesion molecules)

The formation of stable cell contacts is of pivotal importance for every metazoan life form. It is therefore not surprising that adhesive molecules appeared early during the evolution of multicellular organisms. The pioneering work of Johannes Holtfreter and others indicated that adhesive molecules, which reside in the plasma membrane on the surface of most cells, are not only important for establishing general cell adhesion and cellular contacts, but also convey a specific tissue and cellular identity to their host cells (1). Over the last few decades a large number of cell adhesion molecules (CAMs) have been identified and further characterized, and we have learned that the expression of these proteins is highly choreographed in terms of timing and cell identity.

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