IMR Press / FBL / Volume 8 / Issue 3 / DOI: 10.2741/885

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Creating polyketide diversity through genetic engineering
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1 Kosan Biosciences, 3832 Bay Center Place, Hayward, CA 94545, USA

Academic Editor: Jens Eckstein

Front. Biosci. (Landmark Ed) 2003, 8(3), 1–13; https://doi.org/10.2741/885
Published: 1 January 2003
(This article belongs to the Special Issue Current topics in lead discovery)
Abstract

Modular polyketide synthases (PKS) are large multifunctional enzymes that synthesize complex polyketides, a therapeutically important class of natural products. The linear order and composition of catalytic sites that comprise the PKS represent a "code" that determines the identity of the polyketide product. By re-programming the PKS through genetic engineering, it is possible to alter the code in a predictable manner to create specific structural modifications of polyketides and to produce new libraries of these natural products.

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