IMR Press / FBL / Volume 7 / Issue 5 / DOI: 10.2741/means

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Kaposi’s sarcoma associated herpesvirus immune evasion strategies

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1 Department of Microbiology and Molecular Genetics, Division of Tumor Virology, New England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill Drive Southborough, MA 01772
2 Department of Microbiology and Molecular Genetics, Division of Microbiology, New England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill Drive Southborough, MA 01772

Academic Editor: Erle Robertson

Front. Biosci. (Landmark Ed) 2002, 7(5), 185–203; https://doi.org/10.2741/means
Published: 1 May 2002
(This article belongs to the Special Issue DNA viruses and human malignancies)
Abstract

The battle between viruses and their hosts is beautiful in its complexity. The interplay between viral proteins and the immune system has taught researchers much about not just the virus, but also the molecular mechanisms underlying the immune response. With additional evasion strategies constantly being described, this avenue of research is still rich with potential discoveries. In this review, we examine a number of proteins encoded by Kaposi's sarcoma herpesvirus (HHV-8) and detail how they aid the virus in escape from immune system elimination. We include, where possible, examples from other homologous viral systems.

Keywords
KSHV (HHV-8)
Immune evasion
K3
K5
vOX2
vIRF
Review
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