IMR Press / FBL / Volume 7 / Issue 5 / DOI: 10.2741/benitah

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Altered communication between L-type calcium channels and ryanodine receptors in heart failure
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1 INSERM U-390, Montpellier, France

Academic Editor: Hector Valdivia

Front. Biosci. (Landmark Ed) 2002, 7(5), 263–275; https://doi.org/10.2741/benitah
Published: 1 May 2002
(This article belongs to the Special Issue The structure and function of calcium release channels)
Abstract

Heart failure (HF) is a progressive syndrome that appears as the final phase of most cardiac diseases and is manifested as a decreased contractile function. Contraction in cardiomyocytes arises by the Ca2+ induced Ca2+ release mechanism, where Ca2+ entry (ICa) through Ca2+ channels (DHPRs) activates Ca2+ release channels (RyRs) in the junctional sarcoplasmic reticulum (SR). This is the base of cardiac excitation-contraction (EC) coupling. To elucidate the mechanisms underlying depressed function of the failing heart, analysis of EC coupling main elements have been undertaken. ICa density is usually maintained in HF. However, failing myocytes show a reduced SR Ca2+ release. Then, if the trigger of SR Ca2+ release is maintained, why is SR Ca2+ release depressed in HF? Analyses of the DHPR-RyR coupling efficiency have revealed a decrease in the ICa efficacy to trigger Ca2+ release in failing myocytes. In terminal heart failure without hypertrophy, a decrease in SR Ca2+ load can account for the decreased SR Ca2+ release. Fewer Ca2+ sparks (elementary units of SR Ca2+ release) are triggered by an equivalent ICa in hypertrophied failing myocytes, suggesting a functional or spatial reorganization of the space T-tubule junctionnal SR. This theory is supported by new data showing that the T-tubule density is reduced in failing cells.

Keywords
Heart failure
excitation-contraction coupling
Ca2+ signaling
[Ca2+]i transient
Ca2+ sparks
L-type Ca2+ current
Ryanodine receptors
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