IMR Press / FBL / Volume 7 / Issue 4 / DOI: 10.2741/simmen

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Progesterone receptors and Sp/Krüppel-like family members in the uterine endometrium
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1 Arkansas Children’s Nutrition Center and Department of Physiology & Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
Academic Editor:William Okulicz
Front. Biosci. (Landmark Ed) 2002, 7(4), 1556–1565;
Published: 1 June 2002
(This article belongs to the Special Issue Progesterone action and the endometrium)

Sp/KLF family members, of which at least 20 distinct nuclear proteins are known to date, serve as transcription factors by binding to GC-enriched sites within target gene promoters. These molecules regulate diverse cellular processes such as proliferation, differentiation, and apoptosis, via their interactions with various other nuclear proteins in promoter- and cell-context-dependent pathways to effect transactivation or transrepression. Recent studies indicate that Sp-family members may functionally interact with ligand-activated nuclear receptors, especially those for steroid hormones. This review provides a discussion of the putative mechanisms and important participants involved in the crosstalk between selected members of this family and the receptor for the pregnancy hormone progesterone, and the relevant outcomes to the control of the transcriptional network in the uterine endometrium.

Progesterone Receptor
Uterine Endometrium
Transcriptional Control
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