IMR Press / FBL / Volume 7 / Issue 4 / DOI: 10.2741/A857

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Animal models of ultraviolet radiation (UVR)-induced cutaneous melanoma
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1 Department of Cell Biology and Physiology and the Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
Academic Editor:Homer Black
Front. Biosci. (Landmark Ed) 2002, 7(4), 1531–1534;
Published: 1 June 2002
(This article belongs to the Special Issue Photocarcinogenesis)

The incidence of cutaneous melanoma continues to increase in many parts of the world including the United States. The American Cancer Society predicts that there will be approximately 53,600 new cases of melanoma in the United States during 2002 and that there will be 7,400 deaths from melanoma during the same time period. Increased understanding of the underlying mechanisms and risk factors involved in the induction of this deadly disease will require the use of suitable animal models of melanoma. To date, the induction of cutaneous melanoma with ultraviolet radiation (UVR) alone has been observed only in a few diverse animal models: a South American opossum, Monodelphis domestica; a hybrid fish, Xiphophorus; several stocks of transgenic mice; and in Angora goats. Most of these models are not completely suitable due to: 1) the target cell for melanoma formation; 2) the location of the melanocytes in the skin (i.e.- dermal as opposed to epidermal in humans); or 3) problems associated with husbandry and experimental manipulation. Recent studies have identified a mouse, the hepatocyte growth factor/scatter factor (HGF/SF) transgenic mouse, as an attractive model with which to study the induction of melanoma following a single, neonatal exposure to a moderate dose of UVR.

Animal Models
Ultraviolet Radiation
Transgenic Mice
Monodelphis domestica
Angora goat
Hybrid Fish
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