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Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
Article
The link between chromatin structure, protein acetylation and cellular differentiation
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1
Laboratory of Muscle Biology, Muscle Gene Expression Group, NIAMS-IRP, National Institutes of Health, Bethesda, Maryland 20892
2
The Salk Institute for Biological Studies, Peptide Biology Laboratory, La Jolla, California 92093 and Fondazione “A. Cesalpino”, University of Rome La Sapienza, 00161, Rome, Italy
Front. Biosci. (Landmark Ed) 2001, 6(3), 1024–1047;
https://doi.org/10.2741/sartorel
Published: 1 September 2001
Abstract
Chromatin remodeling and protein acetylation control gene expression and consequently regulate cellular growth and differentiation. Here we review the role of individual chromatin remodeling factors, acetyltransferases and deacetylases in the establishment and maintenance of different cell lineages and in the genesis of some human diseases.