IMR Press / FBL / Volume 4 / Issue 4 / DOI: 10.2741/quintana

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The metazoan origin recognition complex
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1 Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Academic Editor:Hisao Masai
Front. Biosci. (Landmark Ed) 1999, 4(4), 805–815; https://doi.org/10.2741/quintana
Published: 1 December 1999
(This article belongs to the Special Issue DNA replication mechanisms and regulation)
Abstract

Regulated initiation of DNA replication relies on the firing of initiator proteins that bind specifically to origin DNA. The discovery of the first eukaryotic initiator, the Saccharomyces cerevisiae Origin Recognition Complex (ORC) has allowed us to discern some aspects of how the onset of replication is regulated. However, understanding the specifics of replication in metazoan organisms can only be achieved by directly addressing these questions in animal cells. This review deals with the current state of knowledge on the metazoan Origin Recognition Complex, its composition and regulation in higher eukaryotes, its role in the initiation of replication and beyond replication, and its possible connection with human pathology.

Keywords
ORC
Origin Recognition Complex
Initiation of DNA Replication
Cell Cycle Control
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