IMR Press / FBL / Volume 29 / Issue 2 / DOI: 10.31083/j.fbl2902068
Open Access Review
Mechanism of Action of the Plateau-Adapted Gene PPARA in COPD
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1 Institute of Public Health, Gansu University of Chinese Medicine, 730000 Lanzhou, Gansu, China
2 Institute of Basic Medicine, Gansu University of Chinese Medicine, 730000 Lanzhou, Gansu, China
*Correspondence: (Xinhua Wang)
Front. Biosci. (Landmark Ed) 2024, 29(2), 68;
Submitted: 21 September 2023 | Revised: 14 November 2023 | Accepted: 21 November 2023 | Published: 20 February 2024
Copyright: © 2024 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Chronic obstructive pulmonary disease (COPD) is a complex respiratory disorder influenced by various factors and involving multiple genes. Respiratory dysfunction in COPD patients leads to hypoxia, resulting in limited oxygen uptake. Peroxisome proliferator-activated receptor alpha (PPARA) is a plateau-adapted gene that regulates respiratory function in populations adapted to high-altitude areas through multiple pathways. Interestingly, PPARA expression is higher in long-term inhabiting Tibetan populations that have adapted to the plateau environment. However, in patients with COPD, the expression of PPARA is downregulated, leading to dysregulation of the hypoxia-inducible factor pathway. Moreover, abnormal PPARA expression in lung epithelial cells triggers inflammatory responses, oxidative stress, and disrupted lipid metabolism, thereby exacerbating disease progression. Thus, this paper explored the mechanism underlying the role of plateau-adapted PPARA in COPD, providing essential theoretical insights into the treatment and prevention of COPD in high-altitude regions.

chronic obstructive pulmonary disease
plateau adaptation genes
inflammatory response
oxidative stress reaction
lipid metabolism
2017YFC0907202/National Key Research and Development Project of China
Fig. 1.
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