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- Academic Editor
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†These authors contributed equally.
Background: Activation of the unfolded protein response (UPR) is
closely related to the pathogenesis of many metabolic disorders. Accumulating
evidence also shows that UPR and metabolic signaling pathways are interdependent.
The AMP-activated protein kinase (AMPK) signal pathway controls the energy
balance of eukaryotes. The aim of this study was therefore to investigate the
possible interaction between AMPK signaling and UPR in muscle cells exposed to
saturated fatty acids, as well as the potential mechanism. Methods: The
saturated fatty acid palmitate was used to induce UPR in C2C12 myotubes. Compound
C or knockdown of AMPK