IMR Press / FBL / Volume 28 / Issue 1 / DOI: 10.31083/j.fbl2801021
Open Access Review
Transgenic Mouse Models for the Study of Neurodegenerative Diseases
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1 Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) – Consejo Superior de Investigaciones Científicas (CSIC), 28130 Valdeolmos, Spain
*Correspondence: (Juan María Torres)
Academic Editors: Fabio Moda and Giorgio Giaccone
Front. Biosci. (Landmark Ed) 2023, 28(1), 21;
Submitted: 7 December 2022 | Revised: 28 December 2022 | Accepted: 5 January 2023 | Published: 19 January 2023
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Neurodegenerative diseases (NDs) are some of the most important health challenges modern medicine and advanced societies face. Indeed, the number of patients affected by one of these illnesses will increase in the following years at the same rate that human life expectancy allows us to live longer. Despite many years of research, NDs remain invariably fatal. A complete understanding of the exact mechanisms leading to neuronal death, which will ideally allow preclinical detection and the development of effective treatments, has not yet been achieved. However, a great deal of information about ND pathology and the search for possible therapies has been acquired using animal models and more precisely transgenic mouse models. In this review, the main contributions of these powerful research tools in NDs as well as their advantages and caveats are discussed.

neurodegenerative diseases
transgenic mice
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