IMR Press / FBL / Volume 24 / Issue 7 / DOI: 10.2741/4782

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Neurodevelopmental disorders with epigenetic dysregulation and Drosophila
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1 Department of Biological Sciences, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea
*Correspondence: islee@konkuk.ac.kr (Im-Soon Lee)
Front. Biosci. (Landmark Ed) 2019, 24(7), 1330–1349; https://doi.org/10.2741/4782
Published: 1 June 2019
(This article belongs to the Special Issue Cutting edge of insect biomedical science)
Abstract

Recently, the mechanisms underlying epigenetic dysregulation associated with neurodevelopmental disorders have attracted increasing attention. Although most neurodevelopmental disorders in humans are multifaceted and encompass a wide range of symptoms, a small number of cases linked to specific single gene disruptions have been identified. The Drosophila genetic system provides excellent models for such diseases. This review will discuss recent advances in the study of human neurodevelopmental disorders associated with epigenetic dysregulation, particularly monogenic disorders established in relevant Drosophila models. Due to the vast range of genes affecting epigenetic dysregulation, we aim to provide a selective review of the disorders caused by aberrant histone modifications, with particular emphasis on enzymes regulating histone acetylation and methylation, in order to give the essential understanding of the nature of the neurodevelopmental disorders for rational therapeutic treatments.

Keywords
Drosophila
Neurodevelopmental disorder
Epigenetic dysregulation
Histone acetylation
Histone methylation
Review
Figures
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